Imlunestrant and Abemaciclib for ER+ Breast Cancer with Minimal Residual Disease
This study, called MIRI, is looking at how well two medicines, imlunestrant and abemaciclib, work together for people with estrogen receptor-positive (ER+) breast cancer. ER+ breast cancer means the cancer cells grow in response to the hormone estrogen. Imlunestrant helps by lowering the amount of estrogen in the body, which can slow cancer growth. Abemaciclib works by blocking certain enzymes that cancer cells need to grow. This trial is for people who have already had treatment for their breast cancer but still have a small amount of cancer cells (minimal residual disease) in their blood. Researchers want to see if these medicines can clear these remaining cancer cells. You can join if you are 18 or older, have ER+ and HER2-negative breast cancer (stages I-III), and meet other specific health criteria. The study aims to see how many people have their circulating tumor DNA (ctDNA) cleared after 12 cycles of treatment. The current status of this study is unclear.
- Study design
- This is an interventional study with a planned enrollment of 42 participants. It is testing two drugs, imlunestrant and abemaciclib, to see their effects.
- What's involved
- You would take abemaciclib twice daily and imlunestrant once daily for up to 12 cycles, with each cycle lasting 28 days. You would also have blood samples collected and may have radiologic scans.
- Compensation
- Not stated in the trial record.
- Follow-up
- After treatment, you would be followed up at 30 days and then every 4 months for one year.
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NCT07191717
Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial
Recruiting
PHASE2Ages 18+InterventionalTreatmentJonsson Comprehensive Cancer CenterInvestigator-initiated
~42 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:AbemaciclibBiospecimen CollectionImlunestrantQuestionnaire AdministrationRadiologic Imaging Procedure
At a glance
Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of circulating tumor deoxyribonucleic acid (ctDNA) clearance
Measured over After 12 cycles (Cycle length = 28 days)
Conditions
Where it's being run
1 sites across 1 statesCalifornia1
Study leadership
- Marla Lipsyc-Sharf · PRINCIPAL_INVESTIGATOR · UCLA / Jonsson Comprehensive Cancer Center
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Participants must have localized ER+ (≥ 10% on surgical pathology), HER2 negative, any grade, invasive breast cancer. Pathological stage (from time of surgery, including patients who received neoadjuvant therapy) I - III by American Joint Committee on Cancer (AJCC) 8th edition staging
Note: Invasive breast cancer must be ER+ in ≥ 10% of the cells and HER2 negative (immunohistochemistry \[IHC\] 0 or 1+ and/or fluorescence in situ hybridization \[FISH\] negative with a ratio \< 2) by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines. For Immunohistochemistry (IHC) 2+, the tumor must be FISH negative with a ratio \< 2. ER, progesterone receptor (PR) and HER2 measurements should be performed according to institutional (local) guidelines, in a Clinical Laboratory Improvement Act (CLIA)-approved setting
Detectable ctDNA in a CLIA-certified lab (separate pre-screening consent available) within the past six months. Participants must have no clinical or radiographic evidence of recurrence as determined by the treating investigator
Confirmation of adequate archival tissue (either initial biopsy or surgical specimen) (15-20 unstained slides cut at 5 µm or 1 block) required before study entry. If adequate surgical tissue is available, this is preferred. Otherwise tissue from diagnostic biopsy is acceptable. If adequate tissue not available, principal investigator (PI) approval is required prior to study entry
No prior history of other malignancies within past 5 years (besides breast cancer as per inclusion #1). Individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: ductal carcinoma in situ of the breast, cervical cancer in situ, melanoma in situ, and basal cell or squamous cell carcinoma of the skin. No concurrent malignancy or other serious medical condition as deemed by the investigator
Participants may or may not have received (neo)adjuvant chemotherapy and/or biological therapy at the time of screening, with no more than grade 1 residual toxicity (except ≤ grade 2 neuropathy or ≤ grade 2 alopecia)
Participants may or may not have received adjuvant radiotherapy, with no more than grade 1 residual toxicity
Pre- and postmenopausal women and men are eligible. Premenopausal women must have a negative serum pregnancy test at time of screening
Pregnancy testing does not need to be pursued in female patients who are:
Age ≥ 60 years; OR
Age \< 60 with intact uterus AND amenorrhea for 12 consecutive months or more AND estrogen (estradiol) levels within postmenopausal range
OR status-post bilateral oophorectomy, total hysterectomy, or bilateral tubal ligation
Must be ≥ 18 years of age
History of CDK 4/6 inhibitor is permitted provided the last dose was more than 6 months ago (from consent date)
Eastern Cooperative Oncology Group (ECOG) performance status 0-1 (Karnofsky ≥ 70%)
Patients must currently be on endocrine therapy in the adjuvant setting and must have received (neo) adjuvant endocrine therapy for at least 24 months (cumulative duration)
Ability to understand and the willingness to sign a written informed consent document. Patient must sign the informed consent (ICF) prior to any screening procedures being performed and is able to comply with protocol requirements
Participants must currently be receiving adjuvant endocrine therapy and have been on adjuvant endocrine therapy for at least 2 years. Adjuvant endocrine therapy can be either tamoxifen or aromatase inhibitor (AI), i.e prior use of any AI, including letrozole, anastrozole or exemestane, or tamoxifen is allowed. Concurrent gonadotrophin releasing hormone (GNRH) agonist is required with AI in pre - and/or peri-menopausal patients and men
Absolute neutrophil count ≥ 1.5 × 10\^9/L
Platelets ≥ 100 × 10\^9/L
Hemoglobin ≥ 9.0 g/dL
Serum creatinine \< 1.5 mg/dL OR creatinine clearance ≥ 50 mL/min
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \< 2.5 x institutional upper limit of normal (ULN)
Total bilirubin \< institutional 1.5 times ULN; or total bilirubin ≤ 3.0 x institutional ULN. Patients with Gilbert's Syndrome with a total bilirubin ≤ 2.0 times ULN and direct bilirubin within normal limits are permitted
The patient is able to swallow oral medications
Exclusion
Participants with metastatic disease (including contralateral axillary lymph nodes) or inflammatory breast cancer. Of note, if a patient had locally advanced breast cancer leading to inflammation, this would not exclude the patient on the grounds of inflammatory carcinoma
Participants who have had CDK 4/6 inhibitor therapy within the past 6 months. Use of prior CDK 4/6 inhibitor with last dose more than 6 months ago is permitted
Participants who are receiving any other anti-cancer investigational agents. Participation in other observational studies is permitted
History of other malignancies within past 5 years, except ductal carcinoma in situ of the breast, cervical cancer in situ, melanoma in situ, and basal cell or squamous cell carcinoma of the skin. No concurrent malignancy or other serious medical condition as deemed by the investigator
Herbal products and supplements will generally not be allowed, but specific supplements (such as cannabidiol \[CBD\] oil) can be considered on a case-by-case basis by Overall PI
Uncontrolled inter-current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, severe renal impairment (e.g. estimated creatinine clearance \< 30ml/min), unstable angina pectoris, cardiac arrhythmia, a preexisting chronic condition resulting in baseline grade 2 or higher diarrhea, or psychiatric illness/social situations that would limit compliance with study requirements. Patients with impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of the study drugs (e.g., ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, stomach resection, or small bowel resection) are ineligible. Patient with active systemic bacterial infection (requiring intravenous \[IV\] antibiotics at time of initiating study treatment), fungal infection, or detectable viral infection (such as known human immunodeficiency virus positivity or with known active hepatitis B or C \[for example, hepatitis B surface antigen positive\]). Screening for HIV and hepatitis is not required for enrollment
The patient has a personal history of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin (including, but not limited to, ventricular tachycardia and ventricular fibrillation), or sudden cardiac arrest
A history of venous thromboembolism (VTE): deep vein thrombus or pulmonary embolism. An exception can be made for patients with a history of an uncomplicated venous catheter-related occlusion. The patient has a personal history of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin (including, but not limited to, ventricular tachycardia and ventricular fibrillation), or sudden cardiac arrest
History of hypersensitivity to imlunestrant, abemaciclib or any of the components in either medication
HIV-positive participants not on antiretroviral therapy are at increased risk of lethal infections when treated with marrow-suppressive therapy and should not be enrolled until their HIV is managed. If the HIV is well controlled, participants may participate in this study
Pregnant women are excluded from this study because embryo-fetal toxicity is a potential side effect of abemaciclib and imlunestrant. For this reason, women of child-bearing potential (WOCBP) and men must agree to use highly effective contraception prior to study entry, for the duration of treatment, and for at least 3 months after the completion of treatment. Should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately. Prior to study enrollment, WOCBP must be advised of the importance of avoiding pregnancy during trial participation and the potential risk factors for an unintentional pregnancy. In addition, men enrolled on this study should understand the risks to any sexual partner of childbearing potential. All WOCBP must have a negative serum pregnancy test within 72 hours prior to receiving the first dose of the investigational agent(s). Registration may occur prior to this pregnancy test. If the pregnancy test is positive, the patient must not receive protocol treatment and must not continue in the study. WOCBP is defined as follows:
Any female who has experienced menarche and who has not undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation, or a bilateral oophorectomy) OR
Any female who is not postmenopausal defined as:
Age ≥ 60 years; OR
Age \< 60 with intact uterus AND amenorrhea for 12 consecutive months or more AND estrogen (estradiol) levels within postmenopausal range; OR
Status-post bilateral oophorectomy, total hysterectomy, or bilateral tubal ligation
Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception throughout the study and for 12 weeks after study drug discontinuation. Women are considered post-menopausal and not of childbearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of childbearing potential. Highly effective contraception methods include:
Total abstinence when this is in line with the preferred and usual lifestyle of the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception
Female sterilization (surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy, or tubal ligation at least six weeks before taking study treatment. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment
Use of non-estrogen oral, injected or implanted hormonal methods of contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS), or other forms of hormonal contraception that have comparable efficacy (failure rate \< 1%), for example hormone vaginal ring or transdermal hormone contraception
Use of luteinizing hormone-releasing hormone (LHRH) agonist with estrogen level in post-menopausal range and one form of barrier method contraception
Women who are lactating. Advise lactating women to not breastfeed during treatment and for 1 week after last dose
What this trial measures
- Rate of circulating tumor deoxyribonucleic acid (ctDNA) clearanceAfter 12 cycles (Cycle length = 28 days)
Clearance of ctDNA is defined as having undetectable plasma ctDNA after completion of 12 cycles of adjuvant imlunestrant and abemaciclib. The rate of ctDNA clearance will be calculated as the percentage of all enrolled patients that have undetectable plasma after completion of adjuvant imlunestrant and abemaciclib (12 cycles or sooner if trial therapy is discontinued), and its Wilson 95% confidence interval will be reported.