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Rapid Immune Modulating Effects of Medicinal Mushrooms

This study is looking at how three different mushroom supplements – Agaricus blazei, Reishi, and Turkey Tail – affect your immune system compared to a placebo (an inactive substance). Researchers want to see if these supplements can quickly change how your immune cells communicate and become more alert. You might be able to join if you are a healthy adult between 18 and 75 years old, have easily visible veins for blood draws, and are willing to follow specific diet and lifestyle routines during the study. The main goal is to measure changes in your immune communication just two hours after taking a study product. The current status of this study is unclear, and it plans to enroll 12 participants.

Study design
This interventional study plans to enroll 12 healthy adults. It compares the effects of three mushroom supplements to a placebo.
What's involved
You would need to maintain a consistent diet and lifestyle, eat bland breakfasts on clinic visit days, and avoid exercise and certain nutrition. Multiple blood draws will be required.
Compensation
Not stated in the trial record.
Follow-up
Immune communication is measured at 2 hours after consuming a test product.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07195552

Clinical Trial: Rapid Immune Modulating Effects

Recruiting
NAAges 18–75InterventionalBasic science
Natural Immune Systems Inc
~12 participants
Updated 2025-09-26 on ClinicalTrials.gov
What's tested:Agaricus blazeiReishiTurkey TailPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Immune Communication
Measured over 2 hours after consuming a test product for this study protocol

Conditions

Immune Surveillance

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Oregon1

Who to contact

Gitte S Jensen, PhD
[email protected]
5418820112
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy adults;
Age 18-75 years (inclusive);
Veins easy to see in one or both arms (to allow for the multiple blood draws);
Willing to comply with study procedures, including:
Maintaining a consistent diet and lifestyle routine throughout the study,
Consistent habit of bland breakfasts on days of clinic visits,
Abstaining from exercising and nutritional supplements on the morn ing of a study visit,
Abstaining from use of coffee, tea, and soft drinks for at least one hour prior to a clinic visit;
Abstaining from music, candy, gum, computer/cell phone use, during clinic visits.

Exclusion

Previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery not a problem, including previous removal of appendix and gall bladder);
Taking anti-inflammatory medications on a daily basis;
Currently experiencing intense stressful events/ life changes;
Currently in intensive athletic training (such as marathon runners);
Currently taking antipsychotic medications such as clozapine, Risperdal, Abilify, Zyprexa or Seroquel;
An unusual sleep routine (examples: working graveyard shift, irregular routine with frequent late nights, studying, partying);
Unwilling to maintain a constant intake of supplements over the duration of the study;
Anxiety about having blood drawn;
Pregnant, nursing, or trying to become pregnant;
Known food allergies related to ingredients in active test product or placebo.

What this trial measures

  • Immune Communication2 hours after consuming a test product for this study protocol

    Changes to serum cytokine levels. The testing involves a broad panel of pro- and anti-inflammatory cytokines, anti-viral peptides, and regenerative growth factors, using a 27-plex Luminex magnetic bead array and the MagPix® multiplexing system. The following cytokines are tested: IL-1beta, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, eotaxin, basic FGF, G-CSF, GM-CSF, IFN-gamma, IP-10, MCP-1 (MCAF), MIP-1alpha, MIP-1beta, PDGF-BB, RANTES, TNF-alpha, and VEGF.