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Portable MRI for Brain Injury After Cardiac Arrest

This study is looking at how well a portable MRI scanner can find brain injury in people who have had a cardiac arrest (when the heart stops beating). Cardiac arrest can lead to brain injury, and doctors currently use tests like conventional MRI to predict recovery. However, conventional MRI requires moving patients, which can be risky for those on life support. This study aims to see if portable MRI, which can be used at the bedside, can accurately detect brain injury. You might be able to join if you are at least 18 years old, unresponsive after your heart restarted, and your doctor thinks a conventional MRI is needed. The study will compare the portable MRI scans to conventional MRI results to see how well they match. The goal is to make brain imaging more accessible and safer for patients after cardiac arrest.

Study design
This is an observational study planning to enroll 60 participants. It will compare portable MRI scans to conventional MRI for measuring brain injury.
What's involved
You would receive 2-3 portable MRI scans: one within 6 hours of cardiac arrest, another between 6-24 hours, and a third around the time of your conventional MRI.
Compensation
Not stated in the trial record.
Follow-up
Brain injury scores will be measured at up to 6 hours, up to 24 hours, and within 12 (+/- 12) hours of conventional MRI.

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NCT07197918

Identification of Brain Injury Using Portable MRI

Recruiting
Not specifiedAges 18+Observational
Yale University
~60 participants
Updated 2026-01-27 on ClinicalTrials.gov
What's tested:portable MRI scanner

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cortex- DGN HIBI score
Measured over up to 6 hours post cardiac arrest, up to 24 hours post cardiac arrest and within 12 (+/- 12) hours of conventional MRI

Conditions

Cardiac Arrest (CA)
Hypoxic-Ischemic Brain Injury

Explore related trials

Cardiac ArrestChronic hypoxic-ischemic brain injury

Where it's being run

1 sites across 1 states
Connecticut1

Study leadership

  • Rachel Beekman, MD · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Rachel Beekman, MD
[email protected]
516-965-4251
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Unresponsive immediately after ROSC from IHCA or OHCA
Age ≥ 18 years of age
Conventional MRI is clinically indicated
Treatment with temperature control

Exclusion

MRI contraindication according to the American Heart Association guidelines
Inability to tolerate supine positioning for 30 minutes
Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC

What this trial measures

  • Cortex- DGN HIBI scoreup to 6 hours post cardiac arrest, up to 24 hours post cardiac arrest and within 12 (+/- 12) hours of conventional MRI

    Hypoxic ischemic brain injury will be assessed using the Cortex- DGN HIBI score on a scale of 0-40. Higher scores indicate greater injury.