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Observational Study on Cystatin C for Early Detection of Acute Kidney Injury

This observational study aims to understand if a blood test for cystatin C (sCyC) can detect acute kidney injury (AKI) earlier than the standard blood test for creatinine (sCr). Researchers are looking at how often AKI occurs when using sCr compared to sCyC, 24-48 hours after receiving contrast media (like isohexol Omnipaque) for a CT scan or coronary angiography, and again 7-10 days later. You may be able to join if you are 18 years or older, are an inpatient with chronic kidney disease (CKD), and are scheduled for a CT scan or coronary angiography involving contrast media. The study is looking to enroll 100 participants. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 100 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed up 24-48 hours after contrast media and again at 7-10 days.

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NCT07197957

Cystatin and Early AKI Detection Contrast Induced Acute Kidney Injury

Recruiting
Not specifiedAges 18+Observational
BayCare Health System
~100 participants
Updated 2025-09-30 on ClinicalTrials.gov

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of AKI when sCr is used compared to when sCyC is used 24-48 hours after contract media and at 7-10 days follow-up
Measured over 10 days

Conditions

Acute Kidney Injury

Explore related trials

Acute Renal FailureChronic Kidney Disease

Where it's being run

4 sites across 1 states
Florida4

Who to contact

Tracy Johns, PharmD
[email protected]
727-519-1310
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subjects ages 18 years and above
Inpatients with CKD (Figure 1)
Order for CT imaging study or coronary angiography with isohexol Omnipaque) contrast media.
Pre and post contrast available
All races and ethnicity of patients are eligible. We expect to analyze approximately equal number of men and women in this study.

Exclusion

Preexisting dialysis
Patients under the age of 18 years
Pregnancy
Incarcerated individuals
Patients with impaired cognition and unable to follow consent procedures
Recent exposure to CM (within 2 days before/after procedure)
Cardiac shock
Medications that affect biomarkers, including corticosteroids, lfamethoxazoletrimethoprim

What this trial measures

  • Incidence of AKI when sCr is used compared to when sCyC is used 24-48 hours after contract media and at 7-10 days follow-up10 days