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Comparing 6-Month vs. 12-Month Follow-up After Large Colon Polyp Removal

This study is looking at the best time for your first follow-up colonoscopy after a large colon polyp (a growth in your large intestine) has been removed. Researchers want to see if having a follow-up at 6 months or 12 months is better at finding any polyps that might grow back (recurrence). You could be eligible if you are 18 or older, are having a colonoscopy, and have had a large polyp (20-50mm, not high-grade dysplasia) removed. The study will measure the rate of recurrence to see which follow-up schedule is more successful. The current status of this study is unclear, but it plans to enroll 546 people.

Study design
This is an interventional study where participants will be randomly assigned to either a 6-month or 12-month follow-up schedule. The study plans to enroll 546 participants.
What's involved
If you join, you will have your first surveillance procedure either 6 months or 12 months after your large polyp was removed. You will also need to complete one electronic survey.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, rate of recurrence, is measured at 1 day, but the follow-up procedures are at 6 or 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07198945

Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection

Enrolling by Invitation
NAAges 18+InterventionalPrevention
Indiana University
~546 participants
Updated 2026-06-17 on ClinicalTrials.gov
What's tested:6-month follow-up12-month follow-up

At a glance

Recruiting sites
0 of 10 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of recurrence
Measured over 1 day

Conditions

Colon Cancer
Colon Polyp
Adenoma
Serrated Polyp
Recurrence, Local Neoplasm
Endoscopic Resection

Explore related trials

AdenomaColon PolypSerrated polyp

Where it's being run

10 sites across 10 states
Alabama1
Colorado1
Illinois1
Indiana1
Kansas1
Massachusetts1
Michigan1
Vermont1

Study leadership

  • John J Guardiola, MD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Familial Adenomatous Polyposis Syndrome
MUTYH associated Polyposis Syndrome
Juvenile Polyposis Syndrome
Cowden's Syndrome
Peutz-Jeghers Syndrome
Hereditary Non-Polyposis Colorectal Cancer Syndrome (HNPCC) or Lynch Syndrome 3. Patients who have high grade dysplasia found in any polyp ≥ 20 mm removed at the index colonoscopy 4. Patients who have any colorectal cancer by histologic diagnosis at index procedure 5. Patients needing a colonoscopy 6 months or sooner for any indication following the index procedure including burden of synchronous disease, inadequate prep to assess for synchronous disease, inadequate prep that precludes resection of index large polyp, or other reason limiting ability to complete full examination of colon at time of resection. 6. ASA ≥ 4 or documented coagulopathy or severe thrombocytopenia (INR ≥ 2 or platelets ≤ 20). 7. Patients who have more than three ≥ 20mm polyps removed during the index colonoscopy 8. Patients with significant acute or chronic medical, neurologic, or illness that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability to complete the study, and/or compromise the objectives of the study.

What this trial measures

  • Rate of recurrence1 day

    Rate of recurrence will be assessed by identification of recurrent polyp tissue at the follow-up procedure.