MAR001 for Elevated Triglycerides

This study is looking at how a drug called MAR001 affects adults who have high levels of triglycerides (a type of fat in the blood). Researchers want to see if MAR001 can lower these triglyceride levels after a meal, compared to a placebo (an inactive substance). You might be able to join if you are between 18 and 75 years old, have elevated triglycerides, and your HbA1c (a measure of blood sugar) is between 5.7% and 8.5%. The study will measure changes in your triglyceride levels 12 weeks after starting the treatment to see if MAR001 is successful. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is an interventional study comparing MAR001 to a placebo. It plans to enroll 30 participants.
What's involved
You would need to provide informed consent and follow all study assessments. You would also need two fasting triglyceride measurements at separate visits during screening, and a stable diet for at least 3 months prior to screening and throughout the study.
Compensation
Not stated in the trial record.
Follow-up
The primary measurements for the study are taken at 12 weeks.

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NCT07199309

A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Marea Therapeutics
~30 participants
Updated 2025-11-06 on ClinicalTrials.gov
What's tested:MAR001Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in TG area under the curve after a mixed meal
Measured over 12 weeks
+1 more outcome measured
Hypertriglyceridemia
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

Willingness to provide informed consent and comply with the intervention and all study assessments
Two fasting TG collected at two separate, consecutive visits at least 7 days apart during the Screening period
HbA1c ≥ 5.7% and ≤ 8.5%
Stable diet for a minimum of 3 months prior to screening and with no plans to change diet through duration of study
Stable drug regimen (appropriate if relevant) prior to screening visit and no planned changes during screening or trial participation

Exclusion

Acute or chronic liver disease
Diabetes medications (other than metformin)
History of type 1 diabetes mellitus or history of diabetic ketoacidosis
Newly diagnosed T2DM
Participants with known active hepatitis A, B, or C
Participants who are known to have uncontrolled human immunodeficiency virus (HIV) infection
Uncontrolled hypothyroidism
Any condition that prevents the participant from complying with study procedures
  • Change from baseline in TG area under the curve after a mixed meal12 weeks
  • Change from baseline in peak plasma TG concentration after a mixed meal12 weeks