Study on Harm Reduction for Cigarette Smoking

This study is looking at ways to help people who smoke cigarettes but aren't ready to quit. It compares two approaches: trying harm reduction products (like e-cigarettes or oral nicotine pouches) versus trying medicinal nicotine products (nicotine patches and lozenges). You would be at least 21 years old, smoke at least 5 cigarettes a day, and be able to communicate in English. The main goal is to see if these approaches help people stop smoking after 29 weeks. The study is currently recruiting about 472 participants, but its status is unclear.

Study design
This interventional study will randomly assign participants to one of two groups: harm reduction products or medicinal nicotine products. Approximately 472 people are planned to join.
What's involved
Participants will try their assigned products for 28 days and complete daily electronic diaries about their smoking and product use.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months, with smoking abstinence measured at 29 weeks.

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NCT07199517

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

Recruiting
NAAges 21+Interventional
Abramson Cancer Center at Penn Medicine
~472 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:HRP Sampling periodNPL Sampling period

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Smoking abstinence
Measured over 29 weeks
Cigarette Smoking
Tobacco Use
Cigarette Smoking Behavior
1 sites across 1 states
Pennsylvania1
  • Janet Audrain-McGovern, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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  • Smoking abstinence29 weeks

    Seven-day point prevalence smoking abstinence (CO \< 5) will be measured at the 3-month (secondary endpoint) and 6-month follow-up (primary endpoint) via the valid and reliable TLFB procedure and biochemically verified through a CO \< 5 ppm.