Psychotherapy for Chronic Stress and Gut Microbiome in Women

This study is exploring if a 6-week group psychotherapy (talk therapy) intervention can change the gut microbiome (the community of bacteria and other microorganisms in your intestines) in women aged 19 to 54 who experience chronic stress. Researchers want to see if chronic stress is linked to the gut microbiome and if therapy can make a difference. You cannot be pregnant, breastfeeding, or already in regular psychotherapy to join. Success would mean seeing improvements in your depression, anxiety, and stress levels, as well as how stressed you feel, after 6 weeks. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is an interventional study planning to enroll 30 women. It is not specified if it is randomized or blinded.
What's involved
You would answer questionnaires about chronic stress, mail a stool sample before and after the intervention, and participate in a 1-hour group therapy session each week for six weeks.
Compensation
Not stated in the trial record.
Follow-up
Your depression, anxiety, stress, and perceived stress will be measured at 6 weeks after starting the intervention.

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NCT07200531

Does Psychotherapy Change the Gut Microbiome in Women of Child-bearing Age?

Recruiting
NAAges 19–54InterventionalSupportive care
University of Nebraska
~30 participants
Updated 2026-03-25 on ClinicalTrials.gov
What's tested:Psychotherapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Depression, Anxiety, and Stress Scales
Measured over 6 weeks
+1 more outcome measured
Chronic Stress
1 sites across 1 states
Nebraska1
  • Ashley J Blount, PhD · PRINCIPAL_INVESTIGATOR · University of Nebraska

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Eligibility criteria

Inclusion

Women over the age of 19 and less than 54. Able to understand/read English

Exclusion

Pregnant women and breast-feeding women Women who are actively participating in psychotherapy on a regular basis
  • Depression, Anxiety, and Stress Scales6 weeks

    Self-report mood disorder questionnaire

  • Perceived Stress6 weeks

    self-report questionnaire of perceived stress