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Electronic Cigarettes for People with Opioid Use Disorder

This study is looking at how different e-cigarette flavors (tobacco-flavored, sweet-cooling, or sweet non-cooling) might help people who smoke cigarettes and also have opioid use disorder (OUD) and are taking buprenorphine. The goal is to see if using e-cigarettes can help reduce the number of regular cigarettes smoked. You might be able to join if you are at least 21 years old, smoke at least 5 cigarettes a day, have OUD, are stable on buprenorphine, and are willing to switch to e-cigarettes. Success in this study means seeing a change in the number of cigarettes you smoke per day over 12 weeks. The current status of this study is unclear.

Study design
This interventional study plans to enroll 90 participants. It will compare the effects of different e-cigarette flavors.
What's involved
You would participate in five brief, individual counseling sessions. The study will track changes in your smoking habits from the beginning up to 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is measured at 12 weeks after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07202039

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

Recruiting
NAAges 21+InterventionalTreatment
Prisma Health-Upstate
~90 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:Brief individual counseling sessions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in cigarettes smoked per day
Measured over Baseline to week 12

Conditions

Tobacco-flavored EC
Sweet-Cooling EC
Sweet Non-cooling EC

Explore related trials

Cigarette SmokingOpioid Use Disorder

Where it's being run

1 sites across 1 states
South Carolina1

Who to contact

Irene Pericot-Valverde, PhD
[email protected]
(864)656-4467
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age ≥21 years
Smoke ≥5 CPD for ≥1 year
Daily CC smoker
Willing to switch to EC
Exhaled CO ≥6 ppm
Diagnosed with OUD
Stable on bupropion treatment
In good physical and mental health
Able to use a smartphone
Willing to participate in all study components

Exclusion

Interested in quitting CC (contemplation stage of change)
Use of EC on ≥4 of the past 30 days
Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days
Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days
Hypertension
Medical condition that would contraindicate participation
Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode
Current suicidal ideation or suicide attempt in the past year
Psychiatric hospitalization in the past year
Contemplating pregnancy, currently pregnant, or breastfeeding
Unable to speak and/or read English

What this trial measures

  • Change in cigarettes smoked per dayBaseline to week 12

    The average change in mean CPD on a 7-day TLFB assessment from baseline (week 0) to weeks 12