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Oral Versus Intravenous Acetaminophen for Postoperative Pain After Lumbar Spine Surgery

This study is looking at whether oral (by mouth) or intravenous (through a vein) acetaminophen (Tylenol) works better to control pain after lumbar spine (lower back) fusion surgery. Researchers want to see if one method is more effective than the other. You might be able to join if you are having open lumbar laminectomy and fusion surgery, are at least 18 years old, and can swallow pills. The study will measure your pain using a scale at different times over 48 hours after surgery. This study is currently unclear on its recruitment status and plans to enroll 180 participants.

Study design
This interventional study is comparing different ways to give acetaminophen or a placebo (inactive substance) to about 180 participants. It is designed to see which method is more effective for pain control.
What's involved
If you join, you would receive either oral or intravenous acetaminophen or a placebo every 6 hours for 48 hours after your spine surgery. Your pain levels will be checked at specific times during this 48-hour period.
Compensation
Not stated in the trial record.
Follow-up
Your pain levels will be measured for 48 hours after surgery, which is the duration of the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07203079

Oral Versus Intravenous Acetaminophen in Lumbar Spine Surgery

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Stanford University
~180 participants
Updated 2025-10-08 on ClinicalTrials.gov
What's tested:Acetaminophen Oral Tabletplacebo oral tabletAcetaminophen infusionPlacebo infusion

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Numerical Rating Scale (NRS) Pain Intensity Scale Score
Measured over postoperative time intervals: 2 hours (baseline), 6 hours, 12 hours, 24 hours, 36 hours, 48 hours

Conditions

Postoperative Pain

Explore related trials

Post-Operative Pain

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Atman Desai, MD · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Plan for open lumbar laminectomy and fusion surgery (1-3 levels)
Able to provide written informed consent
Must be able to swallow pills

Exclusion

Medical contraindications to acetaminophen
Emergency surgery
Chronic pain unrelated to surgery
Pregnancy

What this trial measures

  • Numerical Rating Scale (NRS) Pain Intensity Scale Scorepostoperative time intervals: 2 hours (baseline), 6 hours, 12 hours, 24 hours, 36 hours, 48 hours

    Mean pain intensity scores post-operatively using 11-point Numerical Rating Scale (NRS) (scale ranges from 0 to 10, and higher score means higher pain)