Observational Study on Polycythemia Vera and Thrombocythemia
This is an international study looking back at patient information to understand how essential thrombocythemia (ET) changes into polycythemia vera (PV). Researchers are studying patients who were diagnosed with ET (a condition where your body makes too many platelets) and later developed PV (a condition where your body makes too many red blood cells). They are comparing these patients to others who had ET but did not develop PV. The goal is to learn more about the factors that lead to this change and how it affects patients over time. This study is for adults aged 18 to 100 who had ET and then developed PV by the end of 2020. The study aims to enroll 678 participants.
- Study design
- This is an observational study, meaning researchers are looking at existing medical records. It includes two parts: a nested case-control study and a comparative retrospective cohort study, involving 678 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoints, a nested case-control study and a comparative retrospective cohort study, are measured up to the baseline.
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A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
At a glance
Conditions
Where it's being run
24 sites across 7 statesStudy leadership
- TIZIANO BARBUI, MD · STUDY_DIRECTOR · FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Who to contact
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Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Nested case-control studyUp to the baseline
To identify proliferative risk factors for progression from ET to PV in JAK2V617F positive patients.
- Comparative retrospective cohort studyUp to the baseline
To evaluate the different disease prognosis in ET patients who have progressed to PV compared to de novo PV patients.