Observational Study on Polycythemia Vera and Thrombocythemia

This is an international study looking back at patient information to understand how essential thrombocythemia (ET) changes into polycythemia vera (PV). Researchers are studying patients who were diagnosed with ET (a condition where your body makes too many platelets) and later developed PV (a condition where your body makes too many red blood cells). They are comparing these patients to others who had ET but did not develop PV. The goal is to learn more about the factors that lead to this change and how it affects patients over time. This study is for adults aged 18 to 100 who had ET and then developed PV by the end of 2020. The study aims to enroll 678 participants.

Study design
This is an observational study, meaning researchers are looking at existing medical records. It includes two parts: a nested case-control study and a comparative retrospective cohort study, involving 678 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, a nested case-control study and a comparative retrospective cohort study, are measured up to the baseline.

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NCT07203768

A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes

Recruiting
Not specifiedAges 18+Observational
FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
~678 participants
Updated 2026-07-09 on ClinicalTrials.gov

At a glance

Recruiting sites
10 of 24 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Nested case-control study
Measured over Up to the baseline
+1 more outcome measured
Polycythemia Vera
Thrombocythemia
24 sites across 7 states
Italy15
Germany3
Spain2
Minnesota1
Lombardy1
Veneto1
United Kingdom1
  • TIZIANO BARBUI, MD · STUDY_DIRECTOR · FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

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Eligibility criteria

Exclusion

None.
  • Nested case-control studyUp to the baseline

    To identify proliferative risk factors for progression from ET to PV in JAK2V617F positive patients.

  • Comparative retrospective cohort studyUp to the baseline

    To evaluate the different disease prognosis in ET patients who have progressed to PV compared to de novo PV patients.