Povetacicept for Primary Membranous Nephropathy

This study is looking at how well and how safely povetacicept works for people with primary membranous nephropathy (pMN), a kidney disease. Researchers will compare povetacicept, given as a shot under the skin, with tacrolimus, taken as capsules by mouth. You might be able to join if you are between 18 and 75 years old and have a confirmed diagnosis of pMN. The main goal is to see how many participants achieve a complete clinical remission (CR1) after 104 weeks. The study is currently recruiting about 176 participants, but its status is unclear.

Study design
This interventional study plans to enroll 176 participants. It is evaluating two different treatments: povetacicept and tacrolimus.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at Week 104, suggesting participants will be followed for at least this duration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07204275

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

Recruiting
PHASE2Ages 18–75InterventionalTreatment
Vertex Pharmaceuticals Incorporated
~176 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:PovetaciceptTacrolimus

At a glance

Recruiting sites
111 of 111 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of Participants with Complete Clinical Remission Definition 1 (CR1)
Measured over At Week 104
Primary Membranous Nephropathy
111 sites across 29 states
China34
Japan8
South Korea7
Spain6
United Kingdom6
Brazil5
Italy5
Texas4

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  • Proportion of Participants with Complete Clinical Remission Definition 1 (CR1)At Week 104