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AI-Guided Left Bundle Branch Area Pacing for Heart Failure

This study is looking at a new way to perform Left Bundle Branch Area Pacing (LBBAP), a procedure that helps your heart beat more effectively. It compares LBBAP done with the help of artificial intelligence (AI) to LBBAP done in the usual way. The goal is to see if AI-guided LBBAP leads to better results for people with heart failure. You might be able to join if you are 18 or older, have a weakened heart (Left Ventricular Ejection Fraction or LVEF less than 50%), and certain electrical patterns in your heart (QRS duration 130 ms or more, or already have a device that paces your heart often). The study will measure how well your heart responds to the pacing at the start and after 6 months.

Study design
This is an interventional study comparing two different ways of performing Left Bundle Branch Area Pacing. It plans to enroll 224 participants.
What's involved
Patients will undergo a Left Bundle Branch Area Pacing (LBBAP) procedure, either with or without AI assistance.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure their heart's response at baseline and at 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07206602

AI-Guided Left Bundle Branch Area Pacing

Recruiting
NAAges 18+Interventional
Mayo Clinic
~224 participants
Updated 2026-02-18 on ClinicalTrials.gov
What's tested:AI-assisted Left Bundle Branch Area PacingLeft Bundle Branch Area Pacing

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
CRT response rate
Measured over Baseline, 6 months

Conditions

Heart Failure

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Heart Failure

NCT07206602

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic in Rochester

    Rochester, Minnesotano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Fatima Ezzeddine · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Joseph Abdel Messih
[email protected]
507-422-3967
Email the study team

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Eligibility criteria

Inclusion

Age: 18 years or older.
Left Ventricular Ejection Fraction (LVEF): \<50% within 6 months prior to enrollment.
QRS Duration: Resting QRS duration ≥ 130 ms on ECG OR anticipated right ventricular pacing \> 40% OR device in place with right ventricular pacing \> 40% within 6 months prior to enrollment.
Medical Therapy: Optimized on guideline-directed medical therapy for heart failure.
AI-ECG probability of low LVEF: \>0.5

Exclusion

Age less than 18 years old
Inability to follow-up
Pregnancy

What this trial measures

  • CRT response rateBaseline, 6 months

    CRT response is defined as an absolute increase of \>5% in left ventricular ejection fraction (LVEF) after 6 months of CRT