Cognitive Vitality Pilot Study for Healthy Aging

This study is looking at how a dietary supplement called Axolt Brain Supplement affects thinking skills and overall well-being in adults aged 55 and older. You would take either Axolt or a flavored drink placebo (a substance with no active ingredients) once a day for 45 days. Researchers will measure your memory and other thinking abilities at the beginning and end of the study. To join, you need to be at least 55, live independently, be healthy, and have good vision. The study is looking for 16 participants and its current status is unclear.

Study design
This is a randomized pilot study, meaning participants are assigned by chance to either the Axolt supplement or a placebo. It plans to enroll 16 participants.
What's involved
You would take a dietary supplement daily for 45 days. You would also have a 45-minute assessment at the beginning and again at the end of the study.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive function will be measured from enrollment to the end of treatment at 45 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07208279

Cognitive Vitality Pilot Study

Recruiting
NAAges 55+InterventionalPrevention
Arizona State University
~16 participants
Updated 2025-10-28 on ClinicalTrials.gov
What's tested:Axolt Brain SupplementBolero - Flavored Drink Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Digit Span Forward
Measured over From enrollment to the end of treatment at 45 days.
+7 more outcomes measured
Aging
Healthy Aging
Cognition
Memory
Brain
1 sites across 1 states
Florida1
  • Judith Klein-Seetharaman, PhD · PRINCIPAL_INVESTIGATOR · Arizona State University

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Eligibility criteria

Inclusion

Adults aged 55 years and older
Live independently,
Self-report as healthy
Adequate vision
Fluent in English
No history of mild cognitive impairment
Currently not taking dietary supplements with the same active ingredients in Axolt or naturally flavored water
A Montreal Cognitive Assessment \[12\] (MOCA) score ≥ 24
Able to provide written informed consent, and medical clearance to participate.

Exclusion

Previous participation in a cognitive dietary supplement study in the last 12 months
A score of \< 24 on the Montreal Cognitive Assessment (MoCA) as a potential risk for obtaining informed consent
History of seizures
Epilepsy
Parkinson's disease
History of severe head trauma
Uncontrolled hypertension
On psychoactive medications
Substance abuse
Unwilling or unable to discontinue current dietary supplements with similar ingredients
Planned surgery during the study period
Medications known to interact with active ingredients with Axolt
Minors and prisoners will be excluded.
  • Digit Span ForwardFrom enrollment to the end of treatment at 45 days.

    Digit Span Forward measures short-term memory (5 min.) Score: Min = 2, Max = 8 \*Higher score means better outcome

  • RAVLT LearningFrom enrollment to the end of treatment at 45 days.

    Rey Auditory Verbal Learning Test (RAVLT) Learning assesses short-term memory (10 min). Score: Min = 0, Max = 105 \*Higher score means better outcome

  • Digit Span BackwardFrom enrollment to the end of treatment at 45 days.

    Digit Span Backward measures working memory (5 min.). Score: Min = 2, Max = 8 \*Higher score means better outcome

  • Symbol Digit Modalities Test (SDMT)From enrollment to the end of treatment at 45 days.

    Symbol Digit Modalities Test (SDMT) measures perceptual speed (5 min.). Score: Min = 0, Max = 120 \*Higher score means better outcome

  • RAVLT RecallFrom enrollment to the end of treatment at 45 days.

    Rey Auditory Verbal Learning Test (RAVLT) Recall measures long-term memory (5 min.). Score: Min = 0, Max = 15 \*Higher score means better outcome

  • Brain Fog QuestionnaireFrom enrollment to the end of treatment at 45 days.

    Brain Fog Questionnaire allows entry of self-reported cognitive difficulties (5 min.). Score: Min = 0, Max = 10 \*Lower score means better outcome

  • PHQ-9From enrollment to the end of treatment at 45 days.

    The Patient Health Questionnaire (PHQ-9) records depressive symptoms (5 min.). Score: Min = 0, Max = 27 \*Lower score means better outcome

  • GAD-7From enrollment to the end of treatment at 45 days.

    Generalized Anxiety Disorder 7-item Questionnaire (GAD-7) quantifies anxiety (5 min.). Score: Min = 0, Max = 21 \*Lower score means better outcome