This study is looking at how your body handles fructose, a type of sugar. Researchers want to understand if your small intestine's ability to turn fructose into glucose (a process called gluconeogenesis) helps protect your liver. They are also investigating if this protective effect is different in people with obesity. You might be eligible if you are a healthy adult between 20 and 55 years old, with a BMI (Body Mass Index) that is either in the healthy range (19-25 kg/m2) or the obese range (30-38 kg/m2). The study involves consuming liquid meals with different amounts of fructose and special tracers (13C labeled fructose) given by mouth and intravenously (into a vein). The main goal is to measure how much fructose is converted to glucose in different parts of your body over 6 hours. The current status of this study is unclear.

Study design

This interventional study plans to enroll 40 healthy participants, including those with obesity. Participants will undergo four separate outpatient feeding studies in a crossover fashion.

What's involved

You will have a sugar tolerance test at the start. Then, you will have four separate visits, about three weeks apart, where you will fast overnight, consume liquid meals with tracers, and have blood and urine samples collected frequently over six hours.

Compensation

Not stated in the trial record.

Follow-up

The primary measurements for this study are taken at 6 hours after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.