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Near-infrared Light Therapy for Brain Function and Cognition

This study is testing if a non-invasive treatment called transcranial photobiomodulation (tPBM) can improve brain function and thinking skills in adults. tPBM uses near-infrared light from a device called Vielight Neuro Gamma to stimulate the brain. Researchers want to see if this light therapy can improve how blood flows in the brain (neurovascular coupling) and boost cognitive performance, which includes memory and other thinking abilities. They will compare people who receive the active tPBM treatment with those who receive a sham (inactive) treatment. You might be able to join if you are between 21 and 85 years old, can read and write English, and don't have certain brain conditions. The study aims to enroll 30 participants.

Study design
This is an interventional study comparing an active treatment to a sham treatment, planning to enroll 30 participants.
What's involved
You would participate in a 4-week intervention protocol, with assessments at the beginning and end of this period.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive performance will be measured from the start of the study to a follow-up visit after completing the 4-week intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07209683

The Effect of Near-infrared Light Therapy on Brain Function and Cognition in Young and Older Adults

Recruiting
NAAges 21–85InterventionalTreatment
University of Oklahoma
~30 participants
Updated 2026-02-06 on ClinicalTrials.gov
What's tested:transcranial photobiomodulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cognitive performance
Measured over From baseline visit to the follow-up visit after completing a 4-week intervention protocol

Conditions

Cognition
Neurovascular Coupling Mechanism and Cognitive Function
Neurovascular Control
Brain Aging
Brain Activity

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Where it's being run

1 sites across 1 states
Oklahoma1

Who to contact

Peter Mukli, MD, PhD
[email protected]
+1 (405) 271-8001 · ext. 37745
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age: 21-85 years of age
Adequate hearing and visual acuity to participate in the examinations
Ability to read and write in English
Competence to provide informed consent

Exclusion

Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
Cerebrovascular accident other than TIA within 60 days prior to Visit 0
Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
Participant currently uses commercial brain stimulation / neuromodulation device or an experimental device as part of a research study, e.g. tDCS, tACS, TBS, DBS, TMS, TPBM, etc.
Participant currently takes dietary supplements with an expected cerebrovascular benefit, such as NAD- or NR-supplement, L-citrulline, urolithin
Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, Stage 2 hypertension uncontrolled by medication (\>160/100 mmHg)
Any other medical condition or medication which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol.
Pregnancy or trying to become pregnant in the next 1 months (self-reported), breastfeeding

What this trial measures

  • Cognitive performanceFrom baseline visit to the follow-up visit after completing a 4-week intervention protocol

    Cognitive performance will be assessed by using the following batteries of the NIH Toolbox: 1) Dimensional Change Card Sort \[executive function\]; 2) Pattern Comparison Processing Speed; 3) List Sorting Working Memory; 4) Flanker Inhibitory Control and Attention; 5) Picture Sequencing Memory and/or 6) Oral Symbol Digit Test.