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Understanding Blood Pressure Control After Spinal Cord Injury

This study aims to understand how your body controls blood pressure after a spinal cord injury (SCI), how this control changes over time, and if these changes affect your risk of developing other medical problems. Researchers will use tests like a bolus phenylephrine infusion (a medicine to temporarily change blood pressure) and cold pressor tests on your hand and foot to see how your body responds. They will also use a Valsalva maneuver (a breathing technique) to assess blood pressure regulation. The main goal is to measure the Valsalva maneuver's effect on blood pressure during testing. You may be eligible if you are 18-75 years old with an SCI (C6-T12, ASIA A-D), either acute (less than 3 months since injury) or chronic (more than 1 year since injury). The study plans to enroll 18 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will undergo specific tests. It plans to enroll 18 participants.
What's involved
You would participate in laboratory diagnostic testing sessions, which include tests like phenylephrine infusion, cold pressor tests, and a Valsalva maneuver.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, Valsalva Maneuver Phase II, is measured during the laboratory diagnostic testing session.

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NCT07210437

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

Recruiting
NAAges 18–75InterventionalDiagnostic
Mayo Clinic
~18 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:Tests of sympathetic inhibitionTests of above level sympathetic activationTesting of below level sympathetic activation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Valsalva Maneuver Phase II
Measured over During laboratory diagnostic testing session

Conditions

Spinal Cord Injuries

Explore related trials

Spinal Cord Injury

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Ryan J. Solinsky, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Erin Lund
[email protected]
507-284-9298
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-75 years old
Spinal cord injury with neurological level of injury from C6-T12
ASIA Impairment Scale A-D.
Either acute SCI \<3 months prior (n=10) or chronic SCI (\>1 year since injury, n=8).

Exclusion

Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment);
Women who are pregnant or lactating
Taking or being administered a medication known to potentially have adverse interactions with phenylephrine
In the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.

What this trial measures

  • Valsalva Maneuver Phase IIDuring laboratory diagnostic testing session

    Presence or absence of phase II on Valsalva maneuver testing, which takes approximately 15 seconds to complete. This will be repeated x3.