Observational Study on Circulating Tumor DNA in Breast Cancer

This study is looking at how tiny bits of cancer DNA, called circulating tumor DNA (ctDNA), found in your blood can help doctors understand breast cancer. After you've had your main treatment, even a few remaining cancer cells (minimal residual disease or MRD) can cause cancer to return. By tracking ctDNA through simple blood tests, researchers hope to learn if this can predict if your cancer will come back or if your treatment is working. This is an observational study, meaning there are no new treatments given. It aims to enroll 900 people with different types of breast cancer, including triple-negative (TNBC), HR positive/HER2 negative, and HER2 positive breast cancer. The goal is to improve how doctors manage breast cancer in the future.

Study design
This is an observational study, meaning no new treatments are given. It plans to include 900 participants aged 18 to 99 years old who have been diagnosed with breast cancer.
What's involved
You would need to be willing to participate in the research and provide blood samples. The study does not specify the number of visits or procedures.
Compensation
Not stated in the trial record.
Follow-up
The study will track your Invasive Disease-Free Survival (how long you live without the cancer returning or getting worse) for up to 5 years after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07211178

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Recruiting
Not specifiedAges 18–99Observational
Tempus AI
~900 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:There are no interventions in this observational study.

At a glance

Recruiting sites
14 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Invasive Disease-Free Survival (iDFS) stratified by MRD status during neoadjuvant, post-surgery landmark, post definitive treatment (surveillance), and long-term follow-up
Measured over 5 years
Breast Cancer
TNBC - Triple-Negative Breast Cancer
HR Positive/HER-2 Negative Breast Cancer
HER2 + Breast Cancer
Early Stage Breast Cancer
14 sites across 13 states
Illinois2
Alabama1
California1
Florida1
Indiana1
Michigan1
Missouri1
Nevada1
  • Michelle Ting-Lin, MD · PRINCIPAL_INVESTIGATOR · Tempus AI
GEMINI Breast Clinical Study Manager
Email the study team

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  • Invasive Disease-Free Survival (iDFS) stratified by MRD status during neoadjuvant, post-surgery landmark, post definitive treatment (surveillance), and long-term follow-up5 years