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Observational Study of Collagenase and Colorectal Cancer

This study is looking at how bacteria in your stool (poop) before and after surgery might lead to colorectal (colon or rectal) cancer coming back. Researchers will collect stool, blood, and tumor tissue samples from people having surgery for colon cancer. They want to see if certain bacteria or things they produce encourage tumors to grow after surgery. You can join if you are 18 or older, speak English, and have been diagnosed with colon cancer that needs surgery. The main goal is to measure collagenase activity from when you join until 12 months after surgery to understand how tumors might form after surgery. The study is currently recruiting about 107 participants.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to enroll about 107 participants.
What's involved
You would provide stool, blood, and tissue samples before and after surgery. You will also complete nutritional surveys.
Compensation
Not stated in the trial record.
Follow-up
Collagenase activity will be measured from enrollment up to 12 months after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07211230

Collagenase Biobank Study

Not Yet Recruiting
Not specifiedAges 18+Observational
University of Chicago
~107 participants
Updated 2026-04-09 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Collagenase Activity
Measured over From Enrollment to 12 months postoperative.

Conditions

Colorectal (Colon or Rectal) Cancer

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NCT07211230

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Chicago

    Chicago, Illinoisstudy coordinator listed

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Benjamin P Shogan · PRINCIPAL_INVESTIGATOR · University of Chicago

Who to contact

Benjamin Shogan, MD
[email protected]
(773) 732-2260
Email the study team

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Eligibility criteria

Inclusion

English speaking.
All genders, races, and ethnicities.
Aged greater or equal to 18 years of age.
Ability to understand and the willingness to sign a written informed consent form.
Diagnosed with a colon adenocarcinoma or presumed adenocarcinoma in which surgical resection is recommended.
Have a planned surgical resection of the colon adenocarcinoma at the University of Chicago Comprehensive Cancer Center.
Reside within 150 miles of the University of Chicago Comprehensive Cancer Center.

Exclusion

Stage IV colon adenocarcinoma (known metastatic disease).
Intravenous or oral antibiotic exposure within 30 days of surgery to treat an infection.
Prebiotic exposure within 30 days of surgery.
History of neoadjuvant chemotherapy/radiation to treat the primary colon adenocarcinoma.
History of chemotherapy/radiation to treat a separate malignancy within the last 6 months.
History or current ileostomy or colostomy.
Allergy to perioperative medications (oral neomycin/metronidazole for preoperative bowel preparation, intraoperative prophylactic intravenous cefoxitin).
Patients who are pregnant.
Patients with a history of inflammatory bowel disease.
Patients with a history of bariatric surgery.
History of eating disorders.

What this trial measures

  • Collagenase ActivityFrom Enrollment to 12 months postoperative.

    Measure collagenase activity present within the stool at the time of surgery to determine if it will be significantly higher in patients who later develop recurrence compared to patients who do not. Assessing further if patients who are the most nutritionally at risk for the development of recurrence will have the highest amounts of bacterial collagenase.