Back to search results

PREEVEnT Trial: Plasma Resuscitation for Severe Burns

The PREEVEnT trial is studying whether giving plasma (a part of blood) very early after a severe burn injury is more effective than standard care. This study is for adults aged 18 to 75 who have severe second or third-degree burns covering at least 20% of their body and are expected to be admitted to a burn intensive care unit (ICU). The main goal is to see if early plasma resuscitation can reduce death or long-lasting organ problems within 28 days after the burn. The study plans to enroll about 750 participants. The current recruitment status is unclear.

Study design
This is a Phase 3, open-label, multi-center randomized trial. It plans to enroll approximately 750 adult patients.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 28 days to assess mortality or persistent organ dysfunction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07212998

Plasma Resuscitation Early for Evaluating Volume and Endotheliopathy of Thermal Injury (PREEVEnT) Trial

Not Yet Recruiting
PHASE3Ages 18–75InterventionalTreatment
Jason Sperry
~750 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:PlasmaStandard care

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
28-day Mortality or Persistent Organ Dysfunction
Measured over 28 days

Conditions

Burn Injury
Thermal Burn

Explore related trials

Burn

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Jason Sperry, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Jason Sperry, MD
[email protected]
4128028270
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Estimated ≥ 20% Total Body Surface Area burn/thermal injury with 2nd or 3rd degree depth
Anticipated admission to burn ICU

Exclusion

Estimated rBaux score \<55
Not expected to survive \>24 hours
Wearing NO PREEVENT opt-out bracelet
Age \> 75 or \< 18 years of age
Concomitant traumatic injury with hemorrhagic shock
Isolated chemical burn/injury
Isolated deep electrical burn/injury
Known prisoner
Known pregnancy
Cardiac arrest with \> 5 continuous minutes of CPR
Concern for anoxic injury/ fixed pupils bilaterally
Objection to study voiced by subject or family member at the scene or at the emergency department/burn center

What this trial measures

  • 28-day Mortality or Persistent Organ Dysfunction28 days

    Composite outcome consisting of 28-day all-cause mortality, or 28-day Persistent Organ Dysfunction (POD) requiring support defined as 1) any intravenous vasopressor requirement, or 2) any renal replace therapy, or 3) any ventilator support/mechanical ventilation, or 4) continued need for intensive care unit (ICU) admission at 28 days.