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Observational Study on Follicular Fluid microRNAs in Ovarian Aging

This study is looking at how tiny molecules called microRNAs (miRNAs) in the fluid surrounding eggs (follicular fluid) might be linked to ovarian aging and the success of In Vitro Fertilization (IVF). Researchers want to find non-invasive ways to understand egg quality and a woman's reproductive potential, especially for older women. They will be studying women undergoing IVF treatment who have male factor infertility or other non-ovarian causes. You could join if you are a woman aged under 31 or over 38, have regular menstrual cycles, and are undergoing IVF. The study aims to identify specific miRNAs that change with age and predict IVF outcomes. This is an observational study, meaning no new treatments are given. The study is currently unclear on its status and plans to enroll 100 participants.

Study design
This is an observational study, meaning participants will not receive any interventions. It plans to enroll 100 women.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, such as identifying and validating miRNAs, are measured at 1 year.

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NCT07214246

Follicular Fluid microRNAs in Ovarian Aging and Reproduction

Recruiting
Not specifiedAges 18+Observational
University of Central Florida
~100 participants
Updated 2025-10-09 on ClinicalTrials.gov
What's tested:No Interventions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify exosomal miRNAs using RNA sequencing
Measured over 1 year
+2 more outcomes measured

Conditions

Ovarian Aging
In Vitro Fertilisation (IVF) Treatment
InVitro Fertilization
In Vitro Fertilization Outcome

Explore related trials

Infertility

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Michal Masternak, PhD · PRINCIPAL_INVESTIGATOR · University of Central Florida

Who to contact

Amoy Fraser, PhD, CCRP, PMP
[email protected]
4072668742
Email the study team

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Eligibility criteria

Inclusion

Women undergoing IVF treatment due to male factor infertility or nonovarian causes.
Age groups: younger women \<31 years and older women \>38 years.
Regular menstrual cycles.
Willing and able to provide informed consent.

Exclusion

Minors (under 18 years) and women aged 32-37 years
Diagnosis of polycystic ovarian syndrome (PCOS).
History of recurrent pregnancy loss.
Presence of endometriosis.
Diagnosis of ovarian insufficiency.
Metabolic disorders (e.g., diabetes).
History of ovarian surgery or chemotherapy.
Any condition that might impact follicular fluid quality or IVF outcomes.

What this trial measures

  • Identify exosomal miRNAs using RNA sequencing1 year

    Identify differentially expressed exosomal miRNAs in the follicular fluid of younger (\<31 years) versus older (\>38 years) women undergoing IVF using small RNA sequencing.

  • Validate and assess miRNA for IVF1 year

    Validate the expression of selected miRNAs in an independent sample set and assess their correlation with clinical IVF parameters, including oocyte maturity, fertilization, and embryo development.

  • Determine molecular pathways regulated by age1 year

    Use bioinformatic analysis and in vitro functional assays to determine the molecular pathways regulated by age associated miRNAs, particularly those involved in follicular development, hormone signaling, and cellular aging.