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Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1

This study is exploring a new way to stimulate deep parts of the brain without surgery, using a device called Temporal Interference (TI) Electrical Stimulation. Researchers are testing different types of TI Electrical Stimulation (NAcc TI Active, NAcc TI Sham, NAcc No-TI Active, and NAcc No-TI Sham) to see how they affect brain activity. The main goal is to see if these methods can change brain activity in a specific area called the nucleus accumbens, as measured by an fMRI scan. This study is looking for 30 healthy volunteers between 18 and 50 years old who can speak and read English. You cannot participate if you are taking certain medications or have a history of seizures or migraines.

Study design
This interventional study plans to enroll 30 healthy volunteers. It is designed to compare the effects of different types of Temporal Interference (TI) Electrical Stimulation on brain activity.
What's involved
You would undergo an fMRI scan during active versus sham stimulation, which is expected to take approximately 60 minutes on the study day.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07215299

Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.1

Completed
NAAges 18–50InterventionalBasic science
Indiana University
~30 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Temporal Interference (TI) Electrical Stimulation - NAcc TI ActiveTemporal Interference (TI) Electrical Stimulation - NAcc TI ShamTemporal Interference (TI) Electrical Stimulation - NAcc No-TI ActiveTemporal Interference (TI) Electrical Stimulation - NAcc No-TI Sham

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change From Baseline (no Stimulation) in Brain Activity in the Nucleus Accumbens During Active Versus Sham Stimulation
Measured over During fMRI scanning for each study session (active and sham stimulation), approximately 60 minutes

Conditions

Healthy Volunteers

Explore related trials

Healthy Volunteers

NCT07215299

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Indiana University Bloomington, Imaging Research Facility

    Bloomington, Indianano site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Joshua W Brown, PhD · PRINCIPAL_INVESTIGATOR · Indiana University, Bloomington

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Between the ages of 18 and 50
Must have at least a 6th grade education
Ability to speak and read English for all phases

Exclusion

Currently taking psychotropic medications for ADHD, other mental illness, or medications for cancer
History of epilepsy or seizure disorders
History of migraines or other neurological syndromes
History of AIDS (due to potential cognitive deficits)
History of head trauma or cognitive impairments
Personal experiences consistent with symptoms of psychosis (e.g., hallucinations, delusions of control or special powers)
History of skull defects (e.g., holes bored into the skull or known cranial fissures)
Metal implants in the head or under the scalp
Does not meet fMRI safety screening criteria (e.g., metal implants in the body, permanent jewelry, tattoos on the head or neck)
Uses an intrauterine device (IUD) for birth control and cannot provide documentation to verify MRI safety
Pregnancy (self-reported; no pregnancy test administered)
Weight over 440 lbs (scanner weight limit)
Presence of pacemakers

What this trial measures

  • Change From Baseline (no Stimulation) in Brain Activity in the Nucleus Accumbens During Active Versus Sham StimulationDuring fMRI scanning for each study session (active and sham stimulation), approximately 60 minutes

    Brain activity in the nucleus accumbens was measured using functional magnetic resonance imaging (fMRI) during active temporal interference (TI) brain stimulation compared to sham stimulation. Activity change from baseline (no stimulation) was quantified using region-of-interest (ROI) beta estimates extracted from the nucleus accumbens. The beta estimates were derived from blood-oxygen-level-dependent (BOLD) signal changes measured during fMRI and reflect the magnitude of task-related neural activation within the ROI. Higher beta values indicate greater task-related activation. Whole-brain voxelwise analyses did not identify statistically significant activation clusters after correction for multiple comparisons; therefore, descriptive ROI-level beta estimates are reported.