Exercise and the Tumor Microenvironment in Lung Cancer

This study is investigating how exercise might affect the tumor microenvironment (TME) in patients with non-small cell lung cancer. The TME is the complex environment around a tumor, including cells and other factors that can influence how a tumor grows and responds to treatment. Researchers believe that strenuous exercise could change the TME and the genetic makeup of the tumor, potentially improving the body's immune response against the cancer. They will measure the TME at different times, including before surgery and up to 24 months afterward, to see if exercise makes a difference. You may be able to join if you have lung cancer and are at low risk for exercise testing. The study plans to enroll 48 participants, but its current recruitment status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It aims to enroll 48 participants.
What's involved
You will be offered a lab exercise regimen. For a specific part of the study, only three or four visits are needed, totaling about 4 hours of your time. The first visit is for pre-exercise screening.
Compensation
Not stated in the trial record.
Follow-up
The tumor microenvironment will be measured at baseline, around the time of surgery, and for up to 24 months afterward.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07216209

The Impact of Exercise on the Tumor Microenvironment in Patients With Lung Cancer

Recruiting
NAAges 18+InterventionalPrevention
University of Arizona
~48 participants
Updated 2026-04-21 on ClinicalTrials.gov
What's tested:EXERCISE TRAINING WITH OR WITHOUT MEDICATION

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tumor Microenvironment
Measured over Baseline, Perioperative, up to 24 months
Lung Cancer - Non Small Cell
1 sites across 1 states
Arizona1
  • Stephanie Worrell, MD · PRINCIPAL_INVESTIGATOR · University of Arizona

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

lung cancer
low risk for submaximal exercise testing in accordance with the risk stratification guidelines published by the American Heart Association and the American College of Sports Medicine (AHA/ACSM criteria).

Exclusion

younger than 18 years of age
select a condition on the ACSM-AHA pre-exercise screening questionnaire indicating that physician approval is required prior to exercise
body mass index of \>30 kg/m2
waist girth of \>102cm for men and \>88cm for women
have chronic/debilitating arthritis
have been bedridden in the past three months
have common illness (i.e. colds) within the past 6-weeks
HIV
hepatitis
history of stroke
major affective disorder
autoimmune disease
pregnancy or are breast-feeding
history of severe anaphylactic reaction to an allergen
present with more than one of the following CVD risk factors: family history of myocardial infarction, coronary revascularization, or sudden death before 55 years of age in father or other male first-degree relative or before 65 years of age in mother or other female first-degree relative
  • Tumor MicroenvironmentBaseline, Perioperative, up to 24 months

    Lung cancer specimens will be collected from all patients at the time of surgery. Investigators will perform real-time PCR to identify levels of PDL-1