This observational study is looking into whether small tissue samples taken from your colon during a routine colonoscopy can help detect early signs of Parkinson's disease or REM Sleep Behavior Disorder (RBD). Researchers want to see if they can find a specific protein called alpha-synuclein in these samples, which is known to build up in people with these conditions. Currently, Parkinson's and RBD are diagnosed when symptoms are already noticeable, meaning the disease has progressed. Finding a way to detect it earlier could help doctors start treatments sooner. You might be able to join if you are 40-99 years old, have a diagnosis of Parkinson's or RBD, and are already scheduled for a colonoscopy. The study aims to enroll 40 participants.

Study design

This is an observational study involving 40 participants. It is not testing a new treatment, but rather looking for a biomarker (alpha-synuclein).

What's involved

During your scheduled colonoscopy, doctors will take 4 additional small tissue samples from your colon, which adds about 2 minutes to the procedure. No additional visits are required after the colonoscopy.

Compensation

Not stated in the trial record.

Follow-up

Detection of phosphorylated alpha-synuclein in colon tissue samples is measured at the time of the colonoscopy procedure.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.