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NCT07217249

Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

Enrolling by Invitation
NAAges 30–93InterventionalTreatment
Case Western Reserve University
~570 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Descemet membrane endothelial keratoplasty

At a glance

Recruiting sites
0 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in central corneal endothelial cell density 5 years after Descemet membrane endothelial keratoplasty.
Measured over Subjects are followed for 5 years after corneal transplantation.

Conditions

Fuchs Endothelial Corneal Dystrophy
Corneal Endothelial Decompensation

Explore related trials

Corneal DecompensationFuchs Endothelial Dystrophy

Where it's being run

14 sites across 10 states
Minnesota3
Maryland2
Michigan2
Georgia1
Indiana1
Iowa1
Kansas1
Missouri1

Study leadership

  • Jonathan Lass, MD · PRINCIPAL_INVESTIGATOR · Case Western Reserve University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Willing to return to the study site for follow up at 3 and 5 years after a Descemet membrane endothelial keratoplasty procedure
Fluent in English or Spanish
Willing to have fingerstick blood sample collected to determine HbA1c level
Participated and completed 12-month follow-up in the DEKS study for one or both eyes or a DEKS participant that had a study eye regraft prior to the 12-month visit.

Exclusion

Lack cognitive capacity such that consent could not be provided.

What this trial measures

  • Change in central corneal endothelial cell density 5 years after Descemet membrane endothelial keratoplasty.Subjects are followed for 5 years after corneal transplantation.

    Central corneal endothelial cell density will be assessed by specular microscopy at 3 and 5 years after Descemet membrane endothelial keratoplasty and the results will be compared with the baseline donor endothelial cell density assessed at the eye bank that provided the donor tissue.