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Radiotherapy Compared to Corticosteroid Injection for Hand Osteoarthritis

This study is comparing two treatments for hand and wrist osteoarthritis (OA): low-dose radiotherapy and corticosteroid injections. You may be able to join if you are 50 or older, are a patient at Mayo Clinic in Rochester, MN, and have mild to severe hand OA with pain. The study aims to see which treatment better reduces your pain, measured by a Visual Analog Scale (VAS) score, over a year. The study plans to enroll 165 people, but its current status is unclear.

Study design
This interventional study plans to enroll 165 participants. It compares two different treatments: low-dose radiotherapy and corticosteroid injections.
What's involved
If you receive corticosteroid injections, up to three joints will be treated. If you receive low-dose radiotherapy, you will have 6 treatments given 2-3 times per week, and potentially a second course if needed.
Compensation
Not stated in the trial record.
Follow-up
Your pain will be measured at the start, then monthly for 6 months after treatment, and again at 9 and 12 months after treatment.

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NCT07217405

Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Recruiting
PHASE4Ages 50+InterventionalTreatment
Mayo Clinic
~165 participants
Updated 2026-04-24 on ClinicalTrials.gov
What's tested:Corticosteroid injection (CSI)Low-dose radiotherapy (LDRT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Visual Analog Scale (VAS) score
Measured over Baseline, monthly for 6 months post-intervention, 9 months post-intervention, 12 months post-intervention

Conditions

Osteoarthritis Hand
Osteoarthritis Wrist

Explore related trials

Osteoarthritis

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Terin Sytsma, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Tochukwu Iyke-Nzeocha
[email protected]
(507) 422-3201
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient at Mayo Clinic, Rochester, MN
Age 50 years or older
Mild, moderate, or severe hand OA (Kellgren and Lawrence classification grade 2, 3, or 4) on hand radiographs within the last 24 months
Hand OA pain with a minimum VAS score relating to hand pain of ≥40 (on a 100-point scale) when using the affected hand
Ability to complete study questionnaires

Exclusion

History of previous surgery to the affected hand(s)
Autoimmune joint disease such as rheumatoid arthritis or psoriatic arthritis
Active confounding hand condition such as stenosing tenosynovitis or Dupuytren's contracture
Recent injury (within last 1 month) to the affected hand causing current pain
History of crystalline arthritis (gout or pseudogout) flare in the affected hand(s)
Active use of opioid pain medication(s) or oral steroids within the last 3 months
Fibromyalgia or central sensitization syndrome
Hand CSI or other hand injection within the past 3 months
History of hand LDRT within the past 3 months
Poorly controlled diabetes (HbA1c \> 10%)
Active infection
Current pregnancy

What this trial measures

  • Change in Visual Analog Scale (VAS) scoreBaseline, monthly for 6 months post-intervention, 9 months post-intervention, 12 months post-intervention

    Pain values reported by participants will be assessed using the 100-mm Visual Analogue Scale (VAS). The VAS line will be 100 mm long with no intermediate delineations. Each end will be marked with "no pain" on the left, and "worst possible pain" on the right. Participants will identify their pain level by indicating a point on the line between each end. That point will be measured from the "No pain" end, and the number of millimeters will be reported as the pain score.