NCT07217964

Natural Matrix Protein

Enrolling by Invitation
Not specifiedAges 18+Observational
Hospital for Special Surgery, New York
~100 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:Radiographic Evaluation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Radiographs
Measured over From May 2025 until May 2027
Degenerative Lumbar Spinal Conditions
1 sites across 1 states
New York1
  • Celeste Abjornson, PhD · STUDY_DIRECTOR · Hospital for Special Surgery, New York

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Patients experiencing symptomatic lumbar degenerative disc disease who failed conservative management at up to four vertebral levels between L1-S1 between February 2024 and December 2024.
Adult patients (≥ 18 years old) who underwent lumbar fusion with an NMP graft and interbody cage

Exclusion

Previous lumbar fusion attempts at the level of surgery (adjacent lumbar levels are acceptable)
Active Malignancy
Concurrently under chemotherapy
Active infection at time of surgery
Mentally compromised
Trauma to the operated region
  • RadiographsFrom May 2025 until May 2027

    Radiographic: Imaging assessments will be performed by an independent imaging reviewer. The reviewer will be a musculoskeletal radiologist trained in the schedule of imaging assessments and classification systems for performing each assessment. The reviewer will not have access to clinical outcome data. Plain lateral radiographs at baseline, immediate postoperative, 6-month follow-up, and 1-year follow-up. All radiological measurements will be made using Sectra IDS7 (Sectra AB, Linköping, Sweden). Fusion status on radiographs will be graded at each treated segment from an analysis of three components: bridging bone between the vertebral bodies, angular motion, and translational motion. Fusion Status measured on radiographs was derived from the qualitative assessment of bridging bone and the quantitative assessments of angular and translational Motion. The following grading system was implemented: Not Fused: Absence of bridging bone from endplate to endplate