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NCT07218094

Neuromechanical Mechanisms of Exosuit-assisted Gait Rehabilitation After Stroke

Enrolling by Invitation
EARLY_PHASE1Ages 18+Interventional
Boston University Charles River Campus
~22 participants
Updated 2025-10-20 on ClinicalTrials.gov
What's tested:Walking with robotic ankle assistance

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Dynamic Motor Control Index (DMCI)
Measured over Assisted - Baseline
+4 more outcomes measured

Conditions

Stroke

Explore related trials

Gait Disorders, NeurologicStroke

Where it's being run

1 sites across 1 states
Massachusetts1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

At least 18 years old
\>6 months post-stroke
Observable gait deficits
Able to walk overground and on a treadmill without body-weight support
Able to communicate clearly with investigators and follow instructions
Able to fit the exosuit components, including height between 4'8" and 6'7", weight \< 264lbs, neutral ankle dorsiflexion during standing.

Exclusion

Comorbidities besides stroke that impair walking (musculoskeletal, cardiovascular, pulmonary, or neurological)
Severe pain, neglect, hemianopia, or aphasia limiting comprehension
Unexplained dizziness or more than 2 falls in the previous month
Inability to communicate (as assessed by a licensed physical therapist)
Inability to wear the exosuit due to conditions that require medical management, such as open wounds or broken skin, or as assessed by a licensed physical therapist.

What this trial measures

  • Dynamic Motor Control Index (DMCI)Assisted - Baseline

    Difference in neuromuscular control quality compared to normative data with and without exosuit

  • Correlation Between Propulsion and Weight-Acceptance Motor Modules (Temporal)Assisted - Baseline

    Difference in the merging of motor module structures quantified by correlation coefficient between the propulsion temporal module and weight-acceptance temporal module, computed from EMG data by non-negative matrix factorization, with and without exosuit

  • Correlation Between Weight-Acceptance and Swing-Limb Deceleration Motor Modules (Temporal)Assisted - Baseline

    Difference in the merging of motor module structures quantified by correlation coefficient between the weight-acceptance temporal module and swing-limb deceleration temporal module, computed from EMG data by non-negative matrix factorization, with and without exosuit

  • Variance Accounted For (VAF) by Four Muscle SynergiesAssisted - Baseline

    Difference in the variance in muscle activation accounted for by the 4-synergy model, measuring the quantitative shift in muscle coordination complexity with and without exosuit (%)

  • Paretic PropulsionAssisted - Baseline

    Difference in anterior-posterior ground reaction force with and without exosuit (N)