A Study of Pirtobrutinib for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

This study is looking at the long-term safety of a drug called pirtobrutinib in people who have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) and have been treated before. You can join this study if you are actively participating in or have completed a previous study called J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038). The main goal is to see how many participants experience serious side effects (Grade 3 or higher) from pirtobrutinib. The study plans to enroll about 150 participants and will last approximately 5 years.

Study design
This is an interventional study with a planned enrollment of 150 participants. It is open to adults aged 18 and older.
What's involved
You will receive pirtobrutinib orally every 4 weeks. The study is expected to last about 5 years.
Compensation
Not stated in the trial record.
Follow-up
Your safety will be monitored from the first dose through 30 days after your last dose or the start of new anticancer therapy, whichever comes first.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07218341

A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Recruiting
PHASE4Ages 18+InterventionalTreatment
Eli Lilly and Company
~150 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:PirtobrutinibIdelalisib

At a glance

Recruiting sites
6 of 50 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Participants with a Grade 3 or Higher Treatment-emergent Adverse Events (AEs)
Measured over Time from First Dose of Study Intervention (Study Day 1) through 30 Days After Last Dose of Study Intervention or Start of New Anticancer Therapy, whichever is Earlier
Chronic Lymphocytic Leukemia
Lymphoma, Small Lymphocytic
50 sites across 23 states
China13
Italy7
Poland3
United Kingdom3
New York2
Texas2
Hungary2
Ireland2
  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST) · STUDY_DIRECTOR · Eli Lilly and Company
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Are actively participating in study J2N-MC-JZNN/LOXO-BTK-20020

Exclusion

This is not applicable to this study
  • Percentage of Participants with a Grade 3 or Higher Treatment-emergent Adverse Events (AEs)Time from First Dose of Study Intervention (Study Day 1) through 30 Days After Last Dose of Study Intervention or Start of New Anticancer Therapy, whichever is Earlier