Cannabis Reduction and Functional Outcomes Study

This study is looking at ways to help adults with Cannabis Use Disorder (CUD) reduce their cannabis use. You could be eligible if you are 18 or older, have a CUD diagnosis, and are willing to try to reduce your cannabis use. Participants will receive an 8-week program that includes one session with a therapist for motivational interviewing and goal setting, followed by 7 sessions of computerized cognitive behavioral therapy (CBT4CBT). You may also receive financial incentives for reducing cannabis in your urine. The study aims to see if these interventions improve problems related to cannabis use, sleep, thinking abilities, CUD severity, and overall quality of life. The current status of this study is unclear.

Study design
This interventional study plans to enroll 176 participants. It tests behavioral interventions like computerized cognitive behavioral therapy and motivational interviewing.
What's involved
You would participate in an 8-week intervention. This includes one therapist-led session and seven computerized sessions, plus providing urine samples.
Compensation
Patients will receive contingent reinforcers, which are financial incentives for reduction in urinary cannabinoids.
Follow-up
The primary outcome, cannabis-related problems, is measured at Week 8 (end-of-treatment).

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NCT07218471

Cannabis Reduction and Functional Outcomes

Recruiting
NAAges 18+InterventionalTreatment
Medical University of South Carolina
~176 participants
Updated 2026-03-19 on ClinicalTrials.gov
What's tested:CBT4CBT (Computerized Cognitive Behavioral Therapy)Motivational InterviewingContingency Management

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cannabis-Related Problems
Measured over Week 8 (end-of-treatment)
Cannabis Use Disorder
1 sites across 1 states
South Carolina1
  • Rachel Tomko, PhD. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina
  • Erin McClure, PhD. · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

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Eligibility criteria

Inclusion

Age 18+
Urinary cannabinoid level ≥ 50 ng/mL
DSM-5 diagnosis of CUD (mild, moderate, or severe)
Willingness to attempt cannabis reduction
Completion of Intake Visit

Exclusion

Serious medical/psychiatric conditions
Pregnancy or breastfeeding
Use of cannabis in past 30 days was for medical purposes only
Discontinuation or reduction of cannabis use may exacerbate a pre-existing condition
Cognitive or understanding difficulties, as evidenced by inability to pass informed consent quiz
  • Cannabis-Related ProblemsWeek 8 (end-of-treatment)

    Rutgers Marijuana Problem Index (RMPI)- higher scores associated with worse outcomes.