Investigating Ketosis and Exercise for Brain Health
This study is looking into how a special diet called ketosis (where your body burns fat for energy) and physical activity might affect your brain. Specifically, it wants to see if these things can increase a protein called BDNF (Brain-Derived Neurotrophic Factor), which is important for brain health, and improve your thinking abilities (cognition). Researchers are especially interested in people who have a specific genetic marker called the Met allele from the BDNF Val66Met SNP. You might be able to join if you are a healthy adult between 18 and 35 years old. Participants will receive either d-beta-hydroxybutrate (to induce ketosis) or a placebo. The main goal is to measure your BDNF levels before and after the intervention. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 50 healthy young adults. Participants will be given either d-beta-hydroxybutrate or a placebo.
- What's involved
- Participants will undergo an aerobic treadmill test and have their serum BDNF measured at baseline, before, and immediately after the intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- BDNF levels are measured immediately after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Serum BDNFbaseline, pre-intervention/procedure/surgery, and immediately after the intervention/procedure/surgery
Whole blood will be taken from participants before and after the treadmill test for both placebo and ketosis trial days. Serum will be extracted and an ELIZA will be run to assess serum BDNF concentrations.