This study is looking for healthy adults and those with Metabolic Syndrome, aged 18-45, to understand how Metabolic Syndrome affects blood flow in the brain, especially looking at differences between men and women. You would receive either Indomethacin (a common anti-inflammatory drug) or a placebo (an inactive substance) and undergo MRI scans to measure your brain's blood flow. The goal is to see if Metabolic Syndrome reduces brain blood flow more in women than in men, and if a specific signaling pathway (COX vasodilation) plays a role. The study plans to enroll 72 participants, but its current recruitment status is unclear.

Study design

This interventional study plans to enroll 72 participants, comparing healthy controls with individuals who have Metabolic Syndrome. Participants will receive either Indomethacin or a placebo.

What's involved

You would have a screening visit with a blood test, followed by three laboratory visits, each lasting about 2 hours. These visits, including an MRI scan, must be completed within 6 months.

Compensation

Not stated in the trial record.

Follow-up

Your brain blood flow will be measured over two study visits that must be completed within 6 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.