Adaptive Radiation Therapy for Intermediate- or High-Risk Prostate Cancer

This study is testing a type of radiation therapy called adaptive stereotactic body radiation therapy (SBRT) with a SIB for men with intermediate- or high-risk prostate cancer. Researchers want to find the highest dose of this treatment that is safe and doesn't cause serious side effects. They also want to see if this treatment can target the prostate more precisely, reduce radiation exposure to nearby organs, and improve quality of life by reducing urination-related side effects. You may be able to join if you are a man over 18 with histologically confirmed prostate adenocarcinoma and a good general health status. The study aims to enroll 80 participants. The main measure of success for this study is to see if severe side effects (CTCAE grade ≥ 3) occur within 90 days of treatment. The current recruitment status is unclear.

Study design
This is an interventional study with a planned enrollment of 80 participants. It is a phase 1 dose-finding study, meaning it aims to determine the best dose of the treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be monitored for severe side effects for approximately 100 days after treatment. The study also aims to assess side effects over five years post-treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07219303

Adaptive Radiation Therapy for Men With Intermediate- or High-Risk Prostate Cancer

Recruiting
NAAges 18+InterventionalTreatment
Fox Chase Cancer Center
~80 participants
Updated 2025-10-29 on ClinicalTrials.gov
What's tested:adaptive stereotactic body radiation therapy (SBRT) with a SIB

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Severe (CTCAE grade ≥ 3) treatment-related (possibly, probably or definitely) toxicity occurring within 90 days of treatment.
Measured over From initiation of treatment to 90 days after end of treatment, for a duration of ~100 days.
Prostate Cancer (Adenocarcinoma)
1 sites across 1 states
Pennsylvania1
  • Mark A Hallman, MD, PhD · PRINCIPAL_INVESTIGATOR · FCCC

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  • Severe (CTCAE grade ≥ 3) treatment-related (possibly, probably or definitely) toxicity occurring within 90 days of treatment.From initiation of treatment to 90 days after end of treatment, for a duration of ~100 days.