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Temporal Interference Stimulation for Brain Activity

This study is looking into whether a type of electrical brain stimulation, called Temporal Interference Transcranial electrical stimulation (TI-TES), can temporarily change how different parts of the brain communicate. You would receive either TI-TES, which uses specific electrode patterns to stimulate the brain, or sham stimulation, which feels similar but doesn't deliver continuous stimulation. Researchers will use fMRI (functional magnetic resonance imaging) scans to see if there are changes in how brain regions connect after stimulation. This study is for healthy adults aged 18-50 who are U.S. citizens or permanent residents and speak English. The study is currently unclear on its recruitment status and plans to enroll 40 participants.

Study design
This is an interventional study involving 40 healthy adults. Participants will receive both TI-TES and sham stimulation in a crossover design, meaning they will experience both interventions at different times.
What's involved
You would complete two stimulation phases, one overnight and one during wakefulness. You will also undergo two MRI scans per study phase.
Compensation
Not stated in the trial record.
Follow-up
Changes in brain connectivity will be measured up to 2 weeks after intervention, and differences in these changes between sleep and wake will be assessed at 8 weeks.

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NCT07219719

Temporal Interference for Thalamocortical Activity and Network Modulation

Recruiting
PHASE1Ages 18–50InterventionalBasic science
University of Wisconsin, Madison
~40 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Temporal Interference Transcranial electrical stimulation (TI-TES)Sham stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in thalamocortical functional connectivity (FC): resting state fMRI
Measured over Pre- to post-intervention, up to 2 weeks
+2 more outcomes measured

Conditions

Healthy Participants

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Wisconsin1

Study leadership

  • Larissa Albantakis, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

Who to contact

TITAN Study Team
[email protected]
6082634313
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults aged 18-50
Medically healthy
U.S. citizen or holding permanent resident status
English-speaking

Exclusion

Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)
History of inpatient psychiatric hospitalization
History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions
Current history of poorly controlled headaches including intractable or poorly controlled migraines
Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
Possible pregnancy or plan to become pregnant in the next 6 months (self reported)
Any metal in the head
Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)
Dental implants
Permanent retainers
Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions
Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions
Any medication that may alter seizure threshold taken during the study i.e., Attention-deficit/hyperactivity disorder (ADHD) stimulants (Adderall, amphetamine); Tricyclic/atypical antidepressants (amitriptyline, doxepin, imipramine, maprotiline, nortriptyline, bupropion); SSRIs (Escitalopram, Fluoxetine, Sertraline); Antipsychotics (chlorpromazine, clozapine), Bronchodilators (theophylline, aminophylline); Antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antivirals (valacyclovir, ritonavir); over the counter antihistamines (diphenhydramine, Benadryl); Estradiol-based birth control
Claustrophobia (a fear of small or closed places)
Back problems that would prevent lying flat for up to two hours
Regular night-shift work (second or third shift)
Sleep apnea or other sleep disorder (self-reported)

What this trial measures

  • Change in thalamocortical functional connectivity (FC): resting state fMRIPre- to post-intervention, up to 2 weeks

    Resting-state fMRI will be used to assess changes in thalamocortical functional connectivity before and after repeated thalamic TI-TES delivered during NREM sleep and quiet wakefulness.

  • Difference in magnitude of FC changes between sleep and wake8 weeks

    The magnitude of FC changes between sleep and wake stimulation phases will be evaluated.

  • Difference in spatial distribution of FC changes between sleep and wake8 weeks

    The spatial distribution of FC changes between sleep and wake stimulation phases will be evaluated.