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Low Intensity Focused Ultrasound Stimulation for Stroke Recovery

This study is testing a treatment called Low Intensity Focused Ultrasound Stimulation (LIFUS) for people who have experienced a stroke and have arm weakness. Researchers want to find the best way to use LIFUS to improve brain activity and motor learning skills. They are looking at whether higher power levels of LIFUS are more effective, and which timing (frequency) works best. The study aims to enroll 24 participants aged 21 or older who had a stroke at least six months ago and have ongoing arm weakness. Success will be measured by changes in motor learning and brain excitability immediately after and one hour after the LIFUS treatment.

Study design
This interventional study plans to enroll 24 participants. It will compare different power levels and timings of Low Intensity Focused Ultrasound Stimulation (LIFUS) to a sham (inactive) treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed immediately after the intervention and again one hour later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07220005

Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

Recruiting
NAAges 21+InterventionalTreatment
Duke University
~24 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:Low intensity focused ultrasound stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor sequence learning
Measured over Baseline, immediately after intervention, and 1 hour after intervention
+1 more outcome measured

Conditions

Stroke
Arm Weakness as a Consequence of Stroke
Upper Extremity Hemiparesis
Upper Extremity Impairments
Upper Extremity Weakness

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Stroke

NCT07220005

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Duke University Hospital

    Durham, North Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Wayne Feng, MD MS · PRINCIPAL_INVESTIGATOR · Duke University

Who to contact

Clinical Research Coordinator
[email protected]
919-668-7597
Email the study team

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Eligibility criteria

Inclusion

age \>=21 years old of any gender or race
First-ever ischemic or hemorrhagic stroke (neuroimaging verified) at least 6 months from the stroke onset of symptoms
Unilateral arm weakness measured by the Fugl-Meyer Upper-Extremity Scale ≤ 62/64
Inducible resting motor threshold and testing motor threshold recorded from an affected upper extremity muscle

Exclusion

Bilateral strokes (infarcts and/or hematoma)
Other co-existent neuromuscular disorders affecting upper extremity motor impairment
History of medically uncontrolled depression or other neuropsychiatric disorders despite medications either before or after a stroke that may affect the subject's ability to participate in the study
History of confirmed dementia or taking dementia drugs
Uncontrolled hypertension despite medical treatment(s) at the time of enrollment, defined as SBP≥185 mmHg or DBP≥110 mmHg (patient can be treated, reassessed and enrolled later)
Presence of any MRI/TMS/LIFUS risk factors
Concurrent enrollment in another interventional stroke recovery study
Concerns that the subject cannot comply with study procedures and visits
Pregnant

What this trial measures

  • Motor sequence learningBaseline, immediately after intervention, and 1 hour after intervention

    Motor sequence learning (MSL) involves predictive processing that results in the anticipation of each component of a sequence of actions. MSL will produce response times and the MSL measure will be the number of responders (i.e., those with ≥20% reduction in the response time).

  • Corticospinal excitabilityBaseline, immediately after intervention, and 1 hour after intervention.

    Corticospinal excitability is measured by the peak to peak amplitude of motor evoked potential.