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Impact of Ketone-IQ on Breathing in Healthy Volunteers

This study is looking at how a dietary supplement called Ketone-IQ (1,3 butanediol) affects breathing in healthy adults. Researchers want to see if this supplement, which increases ketone levels in the body, can improve how people breathe. While exogenous ketones (ketones from outside the body) have been studied for energy and exercise, their effect on breathing hasn't been fully explored. This study aims to measure changes in your breathing response (Hypercapnic Ventilatory Response, or HCVR) after you drink Ketone-IQ or a taste-matched placebo. You can join if you are a healthy volunteer between 18 and 50 years old with a BMI between 18 and 30. The study is currently recruiting 20 participants.

Study design
This is a randomized, single-blind, crossover study involving 20 healthy volunteers. Participants will receive either Ketone-IQ or a placebo in two separate visits.
What's involved
You will have two visits, at least 48 hours apart. Each visit involves a medical history, physical exam, a taste test, and breathing measurements before and after drinking the supplement or placebo.
Compensation
Not stated in the trial record.
Follow-up
Your breathing will be measured at baseline and again 2.5 hours after ingesting the study drink during each visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07220122

Impact of Exogenous Ketones on Breathing in Healthy Volunteers

Recruiting
EARLY_PHASE1Ages 18–50InterventionalBasic science
Johns Hopkins University
~20 participants
Updated 2026-03-31 on ClinicalTrials.gov
What's tested:1,3 butanediolPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hypercapnic Ventilatory Response (HCVR)
Measured over During each visit, one measurement at baseline, repeated again 2.5 hours after ingesting Ketone-IQ or Placebo

Conditions

Healthy Volunteer

Explore related trials

Healthy Volunteer

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Jonathan C Jun, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Mariah Potocki
[email protected]
410-550-2233
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

BMI of 18 - 30 kg/m2

Exclusion

No concomitant sleep disorder (e.g. sleep apnea, insomnia, restless leg syndrome, narcolepsy, idiopathic hypersomnia). If there is no known diagnosis of sleep apnea, a STOP-BANG score of 5 or higher is an exclusion.
No current daytime respiratory impairment such as uncontrolled asthma, or uncontrolled Chronic Obstructive Pulmonary Disease (COPD), pneumonia, interstitial lung disease.
No known history of chronic renal disease or diabetes (type 1 or type 2).
No use of supplemental oxygen.
Cannot be on a low carbohydrate (\<130 g carbohydrate/day) or ketogenic diet, intermittent fasting, or consuming exogenous ketones
Cannot be pregnancy or breastfeeding
Cannot be on medications: acetazolamide or Sodium-glucose cotransporter-2 (SGLT2) inhibitor, daily opioid use.
No history of claustrophobia or panic disorder
No frequent alcohol intake (more than 1 drink per day on average, or \> 10 drinks per week).

What this trial measures

  • Hypercapnic Ventilatory Response (HCVR)During each visit, one measurement at baseline, repeated again 2.5 hours after ingesting Ketone-IQ or Placebo

    Minute ventilation (L/min) while breathing 7% Carbon Dioxide (CO2). Measured once during each visit.