Tirzepatide to Slow Biological Aging
This study is looking at whether the drug Zepbound (tirzepatide) can affect how quickly people biologically age. We're inviting 90 adults, aged 55-70, who have a BMI of 30 or higher (or 27 with a weight-related health issue) to participate. Participants will receive weekly Zepbound injections or no drug for 24 weeks. While Zepbound is known for weight loss, this study focuses on its effects on aging markers, physical ability, and overall health. Success would mean seeing a significant change in biological age based on DNA methylation (a way to measure aging at a cellular level). The study status is currently unclear.
- Study design
- This is an interventional study with 90 participants, comparing Zepbound to no drug. Participants are randomly assigned to one of these groups.
- What's involved
- Participants will receive weekly subcutaneous injections for 24 weeks. DNA methylation-based biological age will be measured at the start, and at weeks 4, 12, and 24.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 12 weeks after stopping the drug, making the total study duration 36 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Tirzepatide to Slow Biological Aging
At a glance
Conditions
NCT07220473
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Texas Medical Branch
Galveston, Texasstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Thomas Blackwell, MD, FACP · PRINCIPAL_INVESTIGATOR · University of Texas Medical Branch, Galveston
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in DNA Methylation-Based Biological AgeImmediately before and after the study visit at Weeks 4, 12, and 24
Change in biological age as measured by DNA methylation-based aging clocks (DNAmAge, DNAm PhenoAge, DNAm GrimAge, and DunedinPACE) following tirzepatide treatment.