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Disrupted Sleep and Heart Rhythm in Obstructive Sleep Apnea

This study is looking at how a night of disrupted sleep might affect your heart rhythm, specifically focusing on extra heartbeats (ectopy) or atrial fibrillation (AF). If you have obstructive sleep apnea and an implanted hypoglossal nerve stimulation (HGNS) device, you might be able to join. Researchers will ask you to turn your HGNS device on or off for certain nights over a 14-day period. The main goal is to see how many extra heartbeats you have during these different nights. The study is currently unclear on its recruitment status and plans to enroll 100 participants.

Study design
This is a randomized study with 100 participants. It compares periods of using your HGNS device versus not using it.
What's involved
You would be asked to turn your HGNS device on or off for no more than two consecutive days over a 14-day period. You will also wear an automatic electrocardiographic monitor.
Compensation
Not stated in the trial record.
Follow-up
Your heart rhythm will be monitored over a 24-hour period for the primary endpoint.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07220525

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

Recruiting
NAAges 21+InterventionalTreatment
University of California, San Francisco
~100 participants
Updated 2026-01-23 on ClinicalTrials.gov
What's tested:HGNS Use Randomized Instructions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Ectopic beats
Measured over 24-hour time period

Conditions

Obstructive Sleep Apnea
Premature Ventricular Contraction (PVC)
Atrial Fibrillation (AF)
Premature Atrial Contraction

Explore related trials

Atrial FibrillationAtrial premature complexObstructive Sleep ApneaVentricular premature complex

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Gregory Marcus, MD, MAS · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Hannah Oo, BS
[email protected]
415-476-4999
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Are age 21 years or older
Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health
Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period
Able and willing to provide written informed consent

Exclusion

Currently pregnant or trying to get pregnant
Are currently taking class 1 or 3 anti-arrhythmic medications
Have a history of permanent AF or expected to have continuous AF throughout the study period
Have congenital heart disease
Ventricular pacing \>40%
Are unable to read or sign to provide informed consent

What this trial measures

  • Ectopic beats24-hour time period

    Daily number of ectopic beats as recorded with the adhesive heart monitor