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Cognition and Ultrasound Study

This study is looking at how Low-Intensity Focused Ultrasound (LIFU) neuromodulation, a device that uses sound waves, affects deep parts of the brain and if it can improve thinking skills (cognition). Researchers want to see if LIFU can reach specific brain areas and how it impacts your performance on tests of thinking and memory. You can join if you are a healthy adult, 18 years or older, and speak English. The study aims to enroll 100 participants. The current status of this study is unclear regarding recruitment.

Study design
This is an interventional study planning to enroll 100 healthy participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your performance on thinking tests will be measured at Hour 1 after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07220655

Cognition and Ultrasound

Recruiting
NAAges 18+Interventional
University of Minnesota
~100 participants
Updated 2026-06-15 on ClinicalTrials.gov
What's tested:Low-Intensity Focused Ultrasound (FUS or LIFU)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Deep Brain Targets Reached
Measured over Hour 1
+2 more outcomes measured

Conditions

Healthy Participants

Explore related trials

Healthy Participants

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Michael Bronstein · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

Miriam Freedman
[email protected]
tel:612-625-3330
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18 years of age or older
Speak English (as assessed by their ability to read/answer survey questions)
May be required to score in the appropriate range on self-report measures

Exclusion

They have a neurological disorder which may impact their fMRI scan or cause their reaction to LIFU to differ from that of healthy adults.
They take any psychoactive medication.
They are unable to undergo fMRI scanning due to a contraindication such as claustrophobia, unremovable piercings, pregnancy, the presence of medical devices such as pacemakers, or a movement or sleep disorder.
Are pregnant, or may have reason to believe that they are pregnant.
They have a diagnosis of a psychiatric condition other than depression or anxiety

What this trial measures

  • Deep Brain Targets ReachedHour 1

    MRI-based readouts testing whether LIFU neuromodulation can successfully engage targets in deep brain

  • Multi-Source Interference Test (MSIT) PerformanceHour 1

    Behavioral readouts of successful LIFU neuromodulation of our target regions

  • 28/Posit Science PerformanceHour 1

    Behavioral readouts of successful LIFU neuromodulation of our target regions