Sabroxy® for Insulin Resistance and Mild Cognitive Impairment

This study is testing if a dietary supplement called Sabroxy® can help adults with mild cognitive impairment (problems with memory or thinking) and insulin resistance (when your body doesn't respond well to insulin, a hormone that helps control blood sugar). You might be able to join if you are 40-80 years old, have certain blood sugar and insulin resistance levels, and a specific score on a memory test (MoCA score less than 26). The study will measure changes in your insulin resistance using a test called HOMA-IR. The current status of this study is unclear, and it plans to enroll 140 participants.

Study design
This is a randomized, double-blind, placebo-controlled study involving 120 participants. You will either receive Sabroxy® or an inactive placebo.
What's involved
You would take a capsule once daily after breakfast with water for 8 weeks. You will have assessments at prescreening and at Week 8.
Compensation
Not stated in the trial record.
Follow-up
Your insulin resistance will be measured at prescreening and at Week 8.

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NCT07220694

Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance

Recruiting
NAAges 40–80InterventionalTreatment
SF Research Institute, Inc.
~140 participants
Updated 2026-01-28 on ClinicalTrials.gov
What's tested:Sabroxy®Placebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Insulin Resistance as Assessed by HOMA-IR
Measured over Prescreening -14 days and Week 8
Insulin Resistance
Mild Cognitive Impairment
Cognitive Decline
Neurodegenerative Disorders
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

GROUP 1 = aged 40 - 60, and
GROUP 2 = aged 61 - 80 2. In good general health 3. Screening HOMA-IR value ≥ 2.0 to \< 4.0 4. Screening fasting glucose 100 to 135 mg/dL 5. Screening MoCA less than 26
  • Change in Insulin Resistance as Assessed by HOMA-IRPrescreening -14 days and Week 8

    Insulin resistance will be evaluated using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), calculated from fasting glucose and fasting insulin levels. The objective is to determine the mean change in HOMA-IR from baseline to Week 8 between the Sabroxy® and placebo groups.