Evaluating Calaspargase Pegol Activity in Childhood Leukemia/Lymphoma

This study is looking at how long the medicine calaspargase pegol (Cal-PEG) stays active in the body of children and young adults with acute lymphoblastic leukemia or lymphoma. Researchers want to understand the typical duration of therapeutic serum asparaginase activity (SAA) levels after patients receive Cal-PEG. They also want to see if there's a link between how high the SAA levels get and how long they last, and if this relates to any side effects. You can join if you are 21 years old or younger, have acute lymphoblastic leukemia/lymphoma, and are receiving Cal-PEG as part of your treatment. The study aims to enroll 20 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving you a specific intervention. It plans to include 20 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main measurement for this study will be taken for up to 15 months.

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NCT07221656

Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration

Not Yet Recruiting
Not specifiedUp to 21Observational
Mayo Clinic
~20 participants
Updated 2026-04-02 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Duration of therapeutic SAA
Measured over Up to 15 months
Childhood Acute Lymphoblastic Leukemia
Childhood Lymphoblastic Lymphoma
1 sites across 1 states
Minnesota1
  • Madeleine B. O'Keefe, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic in Rochester

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Eligibility criteria

Inclusion

Acute lymphoblastic leukemia/lymphoma being treated by the pediatric hematology team
Receiving calaspargase as part of treatment for malignancy

Exclusion

Age \> 21 years
Patients who are actively enrolled on Children's Oncology Group (COG) trial AALL1732 in an inotuzumab containing arm
Pregnancy
  • Duration of therapeutic SAAUp to 15 months

    Descriptive statistics including medians and interquartile ranges will be utilized to summarize continuous variables.