This study is looking at how emotions change in people with bipolar disorder (BD) compared to healthy individuals. Researchers want to understand the brain processes that lead to mood instability. You would participate in a task called the Think and Regulate Affective States Task (TReAT) while undergoing an fMRI scan (a type of brain imaging). This task uses your own memories to bring up different emotions. The study aims to see if emotional states can be identified from brain activity and if people with BD have more unstable emotional patterns. They also want to see if making positive emotions stronger can help stabilize mood in BD. The study is currently unclear on its recruitment status and plans to enroll 72 participants. You may be eligible if you are between 18 and 65 years old, fluent in English, and have a diagnosis of Bipolar Disorder I or II (currently depressed or in a mixed state), or are a healthy control.

Study design

This is an interventional study involving 72 participants: 36 with Bipolar Disorder I or II and 36 healthy controls.

What's involved

You would have two visits: one for consent and questionnaires, and another for an MRI scanning session that includes both resting-state and task-based fMRI.

Compensation

Not stated in the trial record.

Follow-up

The primary outcomes, decoded emotional state trajectory and metastability of brain network states, are measured at Day 2.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.