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Spinal Neurorehabilitation for Veterans With Spinal Cord Injuries

This study is looking into how Transcutaneous Spinal Stimulation (a non-invasive electrical stimulation) might help Veterans with chronic spinal cord injuries (SCI). Researchers want to see if this stimulation can improve voluntary movement, sensation, and daily activities. You might be able to join if you are an adult (18 or older) with a chronic SCI that happened more than a year ago, and you can understand study information in English. The study will measure success by looking at changes in your spinal cord using MRI scans and by checking for nerve connections using special tests (transcranial magnetic stimulation) over five years.

Study design
This is an interventional study planning to enroll 40 participants. All participants will receive Transcutaneous Spinal Stimulation.
What's involved
All participants will undergo neurophysiological testing (transcranial magnetic stimulation and somatosensory evoked potentials) and MRI scans of the spine. They will also receive non-invasive transcutaneous spinal stimulation.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for five years to measure changes in their spinal cord and nerve connections.

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NCT07222046

Spinal Neurorehabilitation for Veterans With SCI

Not Yet Recruiting
NAAges 18+InterventionalBasic science
VA Office of Research and Development
~40 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:Neurophysiological and anatomical testingTranscutaneous Spinal Stimulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Axial completeness of chronic spinal cord injury based on spine MRI
Measured over 5 years
+3 more outcomes measured

Conditions

Spinal Cord Injuries

Explore related trials

Spinal Cord Injury

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Jonathan Calvert, MD · PRINCIPAL_INVESTIGATOR · VA Northern California Health Care System, Mather, CA

Who to contact

Jonathan Calvert, MD
[email protected]
(401) 273-7100
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

All participants must be able to independently read and understand study information materials necessary to ensure informed consent.
All participants must have a chronic spinal cord injury occurring \>1 year prior to study enrollment.
Ability to follow simple commands in English.

Exclusion

Contraindications to the use of external magnetic or electrical stimulation (e.g., epilepsy, intracranial metal, implanted electrosensitive device, etc.)
Significant neurological comorbidities that may affect neurophysiological recordings
Functional disability prior to spinal cord injury
Visual or auditory disorders limiting ability to participate in study procedures
Pregnancy
Primary psychiatric disorders or dissociative mental symptoms that impair informed consent
Significant chronic pain that may preclude an MRI scan or performing neurorehabilitation exercises
Frequent and significant spasticity that may preclude an MRI scan or neurorehabilitation exercises.

What this trial measures

  • Axial completeness of chronic spinal cord injury based on spine MRI5 years

    Spared region volume at the injury site as assessed by spine MRI will be compared with clinical SCI score as measured by the ISCNSCI exam.

  • Sagittal completeness of chronic spinal cord injury based on spine MRI5 years

    Intramedullary lesion length will be measured via spine MRI and compared with clinical SCI score as measured by the ISCNSCI exam.

  • Presence of descending connections in chronic spinal cord injury based on transcranial magnetic stimulation5 years

    The latency of transcranial magnetic stimulation pulses will be measured via electromyography and compared with clinical SCI score as measured by the ISCNSCI exam.

  • Presence of ascending connections in chronic spinal cord injury based on somatosensory evoked potentials.5 years

    The latency of somatosensory evoked potential pulses will be measured via electromyography and compared with clinical SCI score as measured by the ISCNSCI exam.