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Tailored Exercise Training for Heart Failure with Preserved Ejection Fraction (HFpEF)

This study is looking at different ways to improve exercise ability in adults with heart failure with preserved ejection fraction (HFpEF) or those at risk for it. HFpEF is a type of heart failure where your heart pumps normally but has trouble relaxing, leading to symptoms like shortness of breath and tiredness. We are testing three approaches: moderate-intensity continuous exercise training, resistance training, and weight loss using medications like semaglutide or tirzepatide. We want to see if these interventions can improve your peak exercise oxygen uptake (VO2peak) and physical performance. We plan to enroll 120 participants. The current status of the study is unclear.

Study design
This interventional study plans to enroll 120 participants. It will compare the effects of four different lifestyle interventions on exercise capacity.
What's involved
Your exercise oxygen uptake and physical performance will be measured at the start of the study, and then again at 3, 6, and 9 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 9 months after starting the study interventions.

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NCT07223242

Tailored Exercise Training Study Among Adults With HFpEF

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of Texas Southwestern Medical Center
~120 participants
Updated 2025-10-31 on ClinicalTrials.gov
What's tested:Moderate-intensity continuous training (MCT)Resistance trainingWeight loss

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Peak Exercise Oxygen Uptake (VO2peak)
Measured over Baseline, 3months, 6months, and 9months
+1 more outcome measured

Conditions

HFpEF - Heart Failure With Preserved Ejection Fraction
Diabetic Cardiomyopathies

Explore related trials

Diabetic cardiomyopathyHeart failure with normal ejection fraction

Where it's being run

1 sites across 1 states
Texas1

Who to contact

Ambarish Pandey, MD
[email protected]
214-645-9868
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

NT-proBNP \>360 pg/mL 2. Risk of HFpEF based on:-
\>2 risk factors (h/o diabetes, hypertension, obesity, physical inactivity by self-report) 4. SPPB \< 10 or VO2\<60th percentile 5. BMI \>=28 (for randomization in phase II) 6. Able to use cell phone and mobile application

What this trial measures

  • Peak Exercise Oxygen Uptake (VO2peak)Baseline, 3months, 6months, and 9months

    VO2peak indexed to body weight (mL/kg/min) will be the co-primary outcome for the trial. VO2peak is a gold-standard measure of aerobic exercise capacity and will be measured by maximal exercise test using a previously established ergometer protocol

  • Short Physical Performance Battery (SPPB)Baseline, 3months, 6months, and 9months

    SPPB will be a co-primary outcome for the trial. Score ranges from 0 to 12, with 0 indicating the worst performance and 12 indicating the best.