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Corticosteroid for Postoperative Pain After Ureteroscopy

This study is looking at whether a corticosteroid called prednisone can help reduce pain after ureteroscopy (a procedure to remove kidney or ureteral stones) and stent placement. You may be able to join if you are at least 18 years old, have kidney or ureteral stones, and are scheduled for ureteroscopy with stent placement. Participants will receive either prednisone (25 mg by mouth, once a day for 5 days after surgery) or a placebo (an inactive pill) in addition to their usual pain medications. The main goal is to see how much your pain changes, measured using a pain scale, from before surgery to Day 1, Day 2, and Day 3 after surgery. The current status of this study is unclear, and it plans to enroll 90 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 90 participants.
What's involved
Participants will take a pill (either prednisone or a placebo) once a day for 5 days after surgery. Pain will be measured at baseline (before surgery), and on Day 1, Day 2, and Day 3 after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for pain measurements until Day 3 after surgery.

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NCT07223580

A Study Of Corticosteroid On Postoperative Pain After Ureteroscopy For Urinary Calculi

Recruiting
PHASE4Ages 18+InterventionalTreatment
Mayo Clinic
~90 participants
Updated 2026-02-03 on ClinicalTrials.gov
What's tested:CorticosteroidPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Visual Analog Scale Pain Score
Measured over Baseline, Day 1 (Post-operatively), Day 2, Day 3

Conditions

Ureteroscopy
Post Operative Pain

Explore related trials

Post-Operative PainUrolithiasis

Where it's being run

1 sites across 1 states
Arizona1

Study leadership

  • Karen L. Stern, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Rev V. Vilasan Shylaja
480-574-1466
Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients who are diagnosed with kidney or ureteral stones confirmed on imaging (CT of the abdomen or pelvis) and who elect for definitive treatment via ureteroscopy with placement of ureteral stent.
Age 18 years or older
Patients of either gender
Patients of all ethnic backgrounds
Cable of giving informed consent
Capable and willing to fulfill the requirements of the study.

Exclusion

History of chronic pain
Chronic use of opioids or other pain medication (\>12 weeks)
Known allergies to corticosteroids.
Known or suspected pregnancy
Inability to give informed consent or unable to meet requirements of the study for any reason.
Bilateral ureteroscopy
Current Corticosteroid Use
Diabetic patients who are insulin dependent

What this trial measures

  • Change in Visual Analog Scale Pain ScoreBaseline, Day 1 (Post-operatively), Day 2, Day 3

    Pain values reported by participants will be assessed using the 100-mm Visual Analogue Scale (VAS). The VAS line will be 100 mm long with no intermediate delineations. Each end will be marked with "no pain" on the left, and "worst possible pain" on the right. Participants will identify their pain level by indicating a point on the line between each end. That point will be measured from the "No pain" end, and the number of millimeters will be reported as the pain score.