Handgrip Training and Brain Blood Flow Regulation Study

This study is looking into how handgrip training affects blood flow in the brain for adults who don't get much exercise. Researchers want to see if doing handgrip exercises three days a week for eight weeks can improve how your brain's blood vessels work. They will measure changes in blood flow in a major brain artery (middle cerebral artery) when you breathe air with extra carbon dioxide. This study is for people aged 18 to 35 who are physically inactive and have a body mass index (BMI) of 30 or less. The goal is to see if handgrip training can improve brain blood vessel function, as previous studies have shown it can help with blood pressure and overall blood vessel health. The study plans to enroll 40 participants.

Study design
This is an interventional study planning to enroll 40 participants, investigating the effects of handgrip training.
What's involved
Participants will engage in handgrip training 3 days per week for 8 weeks. Measurements will be taken up to 9 weeks.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken up to 9 weeks after the start of the study.

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NCT07223645

Handgrip Training and Brain Blood Flow Regulation

Recruiting
NAAges 18–35InterventionalPrevention
Florida State University
~40 participants
Updated 2026-06-25 on ClinicalTrials.gov
What's tested:Handgrip Training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in middle cerebral artery blood velocity reactivity to hypercapnia
Measured over Up to 9 weeks
Inactivity/Low Levels of Exercise
1 sites across 1 states
Florida1

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Eligibility criteria

Inclusion

18 to 35 years old
Body mass index ≤30 kg/m2 (without obesity)
Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months
Have a smartphone and are willing to download mobile applications used in this project

Exclusion

Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.)
Being pregnant, planning to become pregnant, or breastfeeding/lactating
Regular use of nicotine products in the past 6 months
Recent head injury/trauma or concussion
  • Change in middle cerebral artery blood velocity reactivity to hypercapniaUp to 9 weeks

    Middle cerebral artery blood velocity will be measured via transcranial Doppler ultrasound