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Understanding Cryptogenic Stroke and Left Atrial Strain

This study is looking at cryptogenic stroke, a type of stroke where the cause of the blood clot isn't clear. Many people with this type of stroke are at risk for another one. Doctors often recommend blood thinners if an irregular heart rhythm called atrial fibrillation (AF) is found. However, AF can be silent and hard to detect. This study will examine how the left atrium (the heart's upper chamber) functions, specifically looking at something called left atrial strain. When the left atrium doesn't contract normally, blood flow can slow, increasing the risk of clots. Researchers hope to find a link between impaired left atrial strain and cryptogenic stroke, which could help doctors better understand and treat this condition. You may be able to join if you are an adult patient (18-80 years old) who has had a complete heart ultrasound (echocardiography) at UPMC Presbyterian for suspected stroke and have a confirmed stroke diagnosis.

Study design
This is an observational study planning to include 900 participants. It will look back at existing medical information.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will look at the correlation between left atrial strain and cryptogenic stroke at baseline (the start of the study). It is not specified if there is follow-up after this.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07224178

Left Atrial Strain and Cryptogenic Stroke

Recruiting
Not specifiedAges 18+Observational
University of Pittsburgh
~900 participants
Updated 2026-01-07 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation between left atrial strain (percent deformation) and the rate of cryptogenic stroke
Measured over Baseline

Conditions

Ischemic Stroke, Cryptogenic
Ischemic Stroke, Embolic
Hemorrhagic Stroke
Embolic Stroke of Undetermined Source
Recurrent Ischemic Stroke

Explore related trials

Cryptogenic strokeEmbolic Stroke of Undetermined SourceIschemic Stroke

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Leyla E Sade, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh Medical Center

Who to contact

Leyla E Sade, MD
[email protected]
412-215-3464
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adult patients (age \> 18 years and \< 80 years) who had a complete transthoracic echocardiography (TTE) exam at the University of Pittsburgh Medical Center (UPMC) Presbyterian Echocardiography Lab with a referral diagnosis of suspected stroke.

What this trial measures

  • Correlation between left atrial strain (percent deformation) and the rate of cryptogenic strokeBaseline

    Quantitative left atrial (LA) strain (% deformation), measured by speckle-tracking echocardiography from transthoracic echocardiograms obtained during stroke workup, will be compared with the rate of cryptogenic stroke.