This study aims to understand how brain activity in the hippocampus (a part of the brain important for memory and navigation) changes during exploration in people with epilepsy. Researchers will use two approaches: "Visual Exploration" involves cognitive testing while you are admitted to an epilepsy monitoring unit, and "Ambulatory Exploration" involves cognitive tasks during a study visit. The study will look at how brain waves (hippocampal theta power) change under different levels of cognitive effort (high, medium, and low cognitive loads). You may be eligible if you are 18-70 years old, can give informed consent, and either have hippocampal depth electrodes for epilepsy surgery or an implanted RNS device with a hippocampal depth electrode. The study plans to enroll 56 participants.

Study design

This is an interventional study with two main aims, involving surgical epilepsy patients, RNS patients, and healthy controls. It plans to enroll 56 participants.

What's involved

You would participate in cognitive testing sessions, either while admitted to an epilepsy monitoring unit or during a study visit. The number of sessions for visual exploration will vary based on your availability and stamina.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints for hippocampal theta power are measured at a single study visit (Day 1).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.