Back to search results

Lidocaine Infusions for Enhanced Recovery After Non-Cardiac Surgery

This study is looking at how giving intravenous (IV) lidocaine, a common numbing medicine, during and after major non-heart surgeries affects your recovery. Researchers want to see if lidocaine can help you spend less time in the hospital and reduce the amount of pain medication, like opioids, you need. You might be able to join if you are at least 18 years old and are having a major elective surgery that is not on your heart, such as colorectal, urology, or spine surgery. The study is comparing lidocaine to a salt water solution (sodium chloride) to see if lidocaine helps improve recovery and reduce pain after surgery. The study aims to enroll 2290 participants, but its current status is unclear.

Study design
This is a randomized, blinded, placebo-controlled study, meaning participants are randomly assigned to receive either lidocaine or a salt water solution, and neither you nor your doctors will know which you are receiving. It aims to enroll 2290 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your opioid consumption will be measured from the start of study medication up to 72 hours. Your hospital stay length will be measured from admission to discharge, usually 4-7 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07224711

The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Vanderbilt University Medical Center
~2,290 participants
Updated 2026-08-11 on ClinicalTrials.gov
What's tested:Lidocaine HCl 0.8% in D5WSodium Chloride 0.9%

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Case Mix Index-Adjusted Resource Length of Stay (CARLOS)
Measured over Hospital admission to discharge (usually 4-7 days)
+1 more outcome measured

Conditions

Pain
Post Operative Analgesia
Opioid Consumption, Postoperative

Explore related trials

Colon and Rectal SurgeryGeneral SurgerySpine SurgerySurgical OncologyUrologic Surgical ProcedureVentral Hernia Surgery

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Danial Shams, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

Who to contact

Danial Shams, MD
[email protected]
615-936-3198
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age greater than or equal to 18
American Society of Anesthesiologists (ASA) class II-IV
Presenting for major elective, non-cardiac surgery on the colorectal, emergency general surgery, urology, ventral hernia, surgical oncology, or spine services on a weekday
First surgery in the study period (if a patient has multiple surgeries, only the first will be included)

Exclusion

ASA class \>IV
Emergent procedures
Allergy or any contraindication to lidocaine infusion
Patient refusal
Unable to receive or refusal to receive a regional nerve block
Patients who receive an epidural due to standard of care
Direct transfer from operating room to ICU with endotracheal tube in place
Treating team determines patient ineligible prior to study drug administration
Same day surgery
Pregnancy (all female patient of child-bearing age will undergo a pregnancy test the day of surgery)

What this trial measures

  • Case Mix Index-Adjusted Resource Length of Stay (CARLOS)Hospital admission to discharge (usually 4-7 days)

    The difference of CARLOS between the placebo and experimental groups in days. The Case Mix Index-Adjusted Resource Length of Stay is a hospital quality metric that standardizes average length of stay (LOS) to account for the complexity and severity of a hospital's patient population, represented by its Case Mix Index (CMI). A higher CMI indicates a more resource-intensive patient group, while a lower CMI reflects a simpler, less costly case mix.

  • Total Inpatient opioid consumptionStart of study medication to 72 hours

    Total opioid consumption administered during the inpatient stay within the first 72 hours following initiation of the study medication. All opioid doses will be converted to oral morphine milligram equivalents (oMMEs) using standard conversion factors.