Detecting Extrahepatic Metastasis in Colorectal Cancer Liver Metastases

This study is looking for a better way to find if colorectal cancer (cancer that starts in the colon or rectum) that has spread to the liver has also spread to other parts of the body (extrahepatic metastasis). Currently, imaging tests sometimes miss these small or hidden cancer spots. Researchers are testing a new method called EXELION, which looks at tiny particles called exosomes in your blood. These exosomes contain microRNA, which can show how cancer is behaving. The goal is to see if EXELION can find these extra cancer spots more accurately than current methods. You may be able to join if you are an adult with confirmed metastatic colorectal cancer, have pre-treatment blood samples available, and have enough medical information to know if you have extrahepatic metastasis. The main goal is to see how well EXELION can detect these extra cancer spots.

Study design
This is an observational study, meaning participants are not given a specific treatment but are observed. It aims to enroll 500 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, sensitivity, will be measured through study completion, which is an average of 1 year.

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NCT07224724

Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases

Recruiting
Not specifiedAges 18+Observational
City of Hope Medical Center
~500 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:EXELION

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sensitivity
Measured over Through study completion, an average of 1 year
Colorectal Cancer Liver Metastases (CRLM)
Metastatic Colorectal Carcinoma (mCRC)
1 sites across 1 states
California1
  • Ajay Goel, PhD · PRINCIPAL_INVESTIGATOR · City of Hope Medical Center

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Eligibility criteria

Inclusion

Adults (≥18 years old)
Histologically- or cytologically-confirmed colorectal cancer that is metastatic
Availability of pre-treatment plasma samples
Written informed consent provided
Sufficient clinical and imaging data to determine presence/absence of extrahepatic metastasis

Exclusion

Prior malignancies within 5 years
Poor sample quality or hemolysis
Inability to provide informed consent
  • SensitivityThrough study completion, an average of 1 year

    True positive rate: the probability of a positive test result, conditioned on the individual truly being positive